Kimple ME - Search Results

1

EP3 signaling is decoupled from the regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance.

Schaid MD, Harrington JM, Kelly GM, Sdao SM, Merrins MJ, Kimple ME. Schaid MD, et al. Among authors: kimple me. Islets. 2023 Dec 31;15(1):2223327. doi: 10.1080/19382014.2023.2223327. Islets. 2023. PMID: 37415404 Free PMC article.

2

Prostaglandin E2 receptor, EP3, is induced in diabetic islets and negatively regulates glucose- and hormone-stimulated insulin secretion.

Kimple ME, Keller MP, Rabaglia MR, Pasker RL, Neuman JC, Truchan NA, Brar HK, Attie AD. Kimple ME, et al. Diabetes. 2013 Jun;62(6):1904-12. doi: 10.2337/db12-0769. Epub 2013 Jan 24. Diabetes. 2013. PMID: 23349487 Free PMC article.

3

A single-islet microplate assay to measure mouse and human islet insulin secretion.

Truchan NA, Brar HK, Gallagher SJ, Neuman JC, Kimple ME. Truchan NA, et al. Among authors: kimple me. Islets. 2015;7(3):e1076607. doi: 10.1080/19382014.2015.1076607. Islets. 2015. PMID: 26452321 Free PMC article.

4

Synergy Between Gαz Deficiency and GLP-1 Analog Treatment in Preserving Functional β-Cell Mass in Experimental Diabetes.

Brill AL, Wisinski JA, Cadena MT, Thompson MF, Fenske RJ, Brar HK, Schaid MD, Pasker RL, Kimple ME. Brill AL, et al. Among authors: kimple me. Mol Endocrinol. 2016 May;30(5):543-56. doi: 10.1210/me.2015-1164. Epub 2016 Apr 6. Mol Endocrinol. 2016. PMID: 27049466 Free PMC article.

5

Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity.

Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ. Gregg T, et al. Among authors: kimple me. Diabetes. 2016 Sep;65(9):2700-10. doi: 10.2337/db16-0432. Epub 2016 Jun 9. Diabetes. 2016. PMID: 27284112 Free PMC article.

6

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health.

Fontana L, Cummings NE, Arriola Apelo SI, Neuman JC, Kasza I, Schmidt BA, Cava E, Spelta F, Tosti V, Syed FA, Baar EL, Veronese N, Cottrell SE, Fenske RJ, Bertozzi B, Brar HK, Pietka T, Bullock AD, Figenshau RS, Andriole GL, Merrins MJ, Alexander CM, Kimple ME, Lamming DW. Fontana L, et al. Among authors: kimple me. Cell Rep. 2016 Jul 12;16(2):520-530. doi: 10.1016/j.celrep.2016.05.092. Epub 2016 Jun 23. Cell Rep. 2016. PMID: 27346343 Free PMC article. Clinical Trial.

7

Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E₂ Signaling and Enhances Diabetic β-Cell Function.

Neuman JC, Schaid MD, Brill AL, Fenske RJ, Kibbe CR, Fontaine DA, Sdao SM, Brar HK, Connors KM, Wienkes HN, Eliceiri KW, Merrins MJ, Davis DB, Kimple ME. Neuman JC, et al. Among authors: kimple me. Diabetes. 2017 Jun;66(6):1572-1585. doi: 10.2337/db16-1362. Epub 2017 Feb 13. Diabetes. 2017. PMID: 28193789 Free PMC article.

8

The Inhibitory G Protein α-Subunit, Gαz, Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice.

Fenske RJ, Cadena MT, Harenda QE, Wienkes HN, Carbajal K, Schaid MD, Laundre E, Brill AL, Truchan NA, Brar H, Wisinski J, Cai J, Graham TE, Engin F, Kimple ME. Fenske RJ, et al. Among authors: kimple me. Endocrinology. 2017 Jun 1;158(6):1645-1658. doi: 10.1210/en.2016-1700. Endocrinology. 2017. PMID: 28419211 Free PMC article.

9

Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes.

Hernandez R, Graves SA, Gregg T, VanDeusen HR, Fenske RJ, Wienkes HN, England CG, Valdovinos HF, Jeffery JJ, Barnhart TE, Severin GW, Nickles RJ, Kimple ME, Merrins MJ, Cai W. Hernandez R, et al. Among authors: kimple me. Diabetes. 2017 Aug;66(8):2163-2174. doi: 10.2337/db16-1285. Epub 2017 May 17. Diabetes. 2017. PMID: 28515126 Free PMC article.

10

The EP3 Receptor/G_z Signaling Axis as a Therapeutic Target for Diabetes and Cardiovascular Disease.

Schaid MD, Wisinski JA, Kimple ME. Schaid MD, et al. Among authors: kimple me. AAPS J. 2017 Sep;19(5):1276-1283. doi: 10.1208/s12248-017-0097-1. Epub 2017 Jun 5. AAPS J. 2017. PMID: 28584908 Free PMC article. Review.

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