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Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo.
Bahrami E, Schmid JP, Jurinovic V, Becker M, Wirth AK, Ludwig R, Kreissig S, Duque Angel TV, Amend D, Hunt K, Öllinger R, Rad R, Frenz JM, Solovey M, Ziemann F, Mann M, Vick B, Wichmann C, Herold T, Jayavelu AK, Jeremias I. Bahrami E, et al. Among authors: amend d. Mol Cancer. 2023 Jul 8;22(1):107. doi: 10.1186/s12943-023-01803-0. Mol Cancer. 2023. PMID: 37422628 Free PMC article.
Targeting NLRP3 inhibits AML progression by inducing PERK/eIF2-mediated apoptosis.
Luciano M, Sieberer H, Krenn PW, Dang HH, Vetter J, Neuper T, Amend D, Blöchl C, Weichenberger CX, Eglseer A, Unger MS, Andosch A, Steiner P, Neureiter D, Bauer R, Hummer L, Tesanovic S, Binder S, Elmer DP, Strandt H, Schaller S, Strunk D, Pleyer L, Greil R, Winkler S, Hartmann TN, Schmidt-Arras D, Huber CG, Aberger F, Horejs-Hoeck J. Luciano M, et al. Among authors: amend d. Cell Commun Signal. 2024 Sep 2;22(1):424. doi: 10.1186/s12964-024-01777-6. Cell Commun Signal. 2024. PMID: 39223663 Free PMC article.
Transcriptional control of leukemogenesis by the chromatin reader SGF29.
Barbosa K, Deshpande A, Perales M, Xiang P, Murad R, Pramod AB, Minkina A, Robertson N, Schischlik F, Lei X, Sun Y, Brown A, Amend D, Jeremias I, Doench JG, Humphries RK, Ruppin E, Shendure J, Mali P, Adams PD, Deshpande AJ. Barbosa K, et al. Among authors: amend d. Blood. 2024 Feb 22;143(8):697-712. doi: 10.1182/blood.2023021234. Blood. 2024. PMID: 38048593
WT1 and DNMT3A play essential roles in the growth of certain patient AML cells in mice.
Ghalandary M, Gao Y, Amend D, Kutkaite G, Vick B, Spiekermann K, Rothenberg-Thurley M, Metzeler KH, Marcinek A, Subklewe M, Menden MP, Jurinovic V, Bahrami E, Jeremias I. Ghalandary M, et al. Among authors: amend d. Blood. 2023 Feb 23;141(8):955-960. doi: 10.1182/blood.2022016411. Blood. 2023. PMID: 36256915 Free article. No abstract available.
CRISPR/Cas9-mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients.
Nasri M, Ritter M, Mir P, Dannenmann B, Aghaallaei N, Amend D, Makaryan V, Xu Y, Fletcher B, Bernhard R, Steiert I, Hahnel K, Berger J, Koch I, Sailer B, Hipp K, Zeidler C, Klimiankou M, Bajoghli B, Dale DC, Welte K, Skokowa J. Nasri M, et al. Among authors: amend d. Haematologica. 2020 Mar;105(3):598-609. doi: 10.3324/haematol.2019.221804. Epub 2019 Jun 27. Haematologica. 2020. PMID: 31248972 Free PMC article.
41 results