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Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo.
Bahrami E, Schmid JP, Jurinovic V, Becker M, Wirth AK, Ludwig R, Kreissig S, Duque Angel TV, Amend D, Hunt K, Öllinger R, Rad R, Frenz JM, Solovey M, Ziemann F, Mann M, Vick B, Wichmann C, Herold T, Jayavelu AK, Jeremias I. Bahrami E, et al. Among authors: ludwig r. Mol Cancer. 2023 Jul 8;22(1):107. doi: 10.1186/s12943-023-01803-0. Mol Cancer. 2023. PMID: 37422628 Free PMC article.
FBXL6 is a vulnerability in AML and unmasks proteolytic cleavage as a major experimental pitfall in myeloid cells.
Sperk A, Gabriel A, Koch D, Augsburger A, Sanchez V, Brockelt D, Öllinger R, Engleitner T, Giansanti P, Ludwig R, Auf der Maur P, Walter W, Haferlach T, Jeremias I, Rad R, Steigenberger B, Kuster B, Eichner R, Bassermann F. Sperk A, et al. Among authors: ludwig r. Leukemia. 2024 Sep;38(9):2027-2031. doi: 10.1038/s41375-024-02345-0. Epub 2024 Jul 16. Leukemia. 2024. PMID: 39014197 Free PMC article. No abstract available.
Autophagy in mesenchymal progenitors protects mice against bone marrow failure after severe intermittent stress.
Landspersky T, Saçma M, Rivière J, Hecker JS, Hettler F, Hameister E, Brandstetter K, Istvánffy R, Romero Marquez S, Ludwig R, Götz M, Buck M, Wolf M, Schiemann M, Ruland J, Strunk D, Shimamura A, Myers K, Yamaguchi TP, Kieslinger M, Leonhardt H, Bassermann F, Götze KS, Geiger H, Schreck C, Oostendorp RAJ. Landspersky T, et al. Among authors: ludwig r. Blood. 2022 Feb 3;139(5):690-703. doi: 10.1182/blood.2021011775. Blood. 2022. PMID: 34657154 Free PMC article.
Biological, as opposed to classic antipsoriatic drug or apremilast, treatment mitigates the risk of death and cardiovascular disease in psoriasis.
Kridin K, Bieber K, Vorobyev A, Moderegger EL, Olbrich H, Ludwig MA, Gershater B, Hernandez G, Zirpel H, Thaci D, Ludwig RJ. Kridin K, et al. Among authors: ludwig rj. EBioMedicine. 2024 Dec 6;111:105485. doi: 10.1016/j.ebiom.2024.105485. Online ahead of print. EBioMedicine. 2024. PMID: 39644770 Free PMC article.
Dexamethasone's Clinical Efficacy in Experimental Autoimmune Pancreatitis Correlates with a Unique Transcriptomic Signature, Whilst Kinase Inhibitors Are Not Effective.
Agrifoglio O, Kasprick A, Gross N, Wahlig M, Kauffold E, Woitas A, Vorobyev A, Ehlers L, Ludwig RJ, Bieber K, Jaster R. Agrifoglio O, et al. Among authors: ludwig rj. Biomedicines. 2024 Oct 29;12(11):2480. doi: 10.3390/biomedicines12112480. Biomedicines. 2024. PMID: 39595046 Free PMC article.
1,131 results