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Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR.
Jörg M, van der Westhuizen ET, Lu Y, Christopher Choy KH, Shackleford DM, Khajehali E, Tobin AB, Thal DM, Capuano B, Christopoulos A, Valant C, Scammells PJ. Jörg M, et al. Among authors: thal dm. Eur J Med Chem. 2023 Oct 5;258:115588. doi: 10.1016/j.ejmech.2023.115588. Epub 2023 Jul 1. Eur J Med Chem. 2023. PMID: 37423123 Free PMC article.
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
Thal DM, Sun B, Feng D, Nawaratne V, Leach K, Felder CC, Bures MG, Evans DA, Weis WI, Bachhawat P, Kobilka TS, Sexton PM, Kobilka BK, Christopoulos A. Thal DM, et al. Nature. 2016 Mar 17;531(7594):335-40. doi: 10.1038/nature17188. Epub 2016 Mar 9. Nature. 2016. PMID: 26958838 Free PMC article.
The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor.
Draper-Joyce CJ, Michino M, Verma RK, Klein Herenbrink C, Shonberg J, Kopinathan A, Scammells PJ, Capuano B, Thal DM, Javitch JA, Christopoulos A, Shi L, Lane JR. Draper-Joyce CJ, et al. Among authors: thal dm. Biochem Pharmacol. 2018 Feb;148:315-328. doi: 10.1016/j.bcp.2018.01.002. Epub 2018 Jan 9. Biochem Pharmacol. 2018. PMID: 29325769 Free PMC article.
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.
Liang YL, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang MW, Miller LJ, Christopoulos A, Sexton PM, Wootten D. Liang YL, et al. Among authors: thal dm. Nature. 2018 Mar 1;555(7694):121-125. doi: 10.1038/nature25773. Epub 2018 Feb 21. Nature. 2018. PMID: 29466332
Structure of the adenosine-bound human adenosine A1 receptor-Gi complex.
Draper-Joyce CJ, Khoshouei M, Thal DM, Liang YL, Nguyen ATN, Furness SGB, Venugopal H, Baltos JA, Plitzko JM, Danev R, Baumeister W, May LT, Wootten D, Sexton PM, Glukhova A, Christopoulos A. Draper-Joyce CJ, et al. Among authors: thal dm. Nature. 2018 Jun;558(7711):559-563. doi: 10.1038/s41586-018-0236-6. Epub 2018 Jun 20. Nature. 2018. PMID: 29925945
47 results