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Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening.
Deng D, Yang Y, Zou Y, Liu K, Zhang C, Tang M, Yang T, Chen Y, Yuan X, Guo Y, Zhang S, Si W, Peng B, Xu Q, He W, Xu D, Xiang M, Chen L. Deng D, et al. Among authors: chen l, chen y. J Med Chem. 2023 Jul 27;66(14):9495-9518. doi: 10.1021/acs.jmedchem.3c00082. Epub 2023 Jul 12. J Med Chem. 2023. PMID: 37438997
Discovery, Optimization, and Evaluation of Potent and Selective DNA-PK Inhibitors in Combination with Chemotherapy or Radiotherapy for the Treatment of Malignancies.
Liu K, Yuan X, Yang T, Deng D, Chen Y, Tang M, Zhang C, Zou Y, Zhang S, Li D, Shi M, Guo Y, Zhou Y, Zhao M, Yang Z, Chen L. Liu K, et al. Among authors: chen l, chen y. J Med Chem. 2024 Jan 11;67(1):245-271. doi: 10.1021/acs.jmedchem.3c01338. Epub 2023 Dec 20. J Med Chem. 2024. PMID: 38117951
Design, Synthesis, and Biological Evaluation of 5-Amino-4-fluoro-1H-benzo[d]imidazole-6-carboxamide Derivatives as Novel and Potential MEK/RAF Complex Inhibitors Based on the "Clamp" Strategy.
Wang P, Yuan Y, Yang T, Zou Y, Tang M, Ma Z, Bo W, Qin S, Chen Y, Guo T, Guo Z, Yang J, Xiang M, Chen L. Wang P, et al. Among authors: chen l, chen y. J Med Chem. 2024 Sep 12;67(17):15246-15267. doi: 10.1021/acs.jmedchem.4c00860. Epub 2024 Aug 21. J Med Chem. 2024. PMID: 39166848
Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1.
Tellis JC, Wei B, Siu M, An L, Chan GK, Chen Y, Du X, Gazzard L, Hu B, Kiefer J, Kakiuchi-Kiyota S, Lainchbury M, Linehan JL, Luo X, Malhotra S, Mendonca R, Pang J, Ran Y, Sethuraman V, Seward E, Sneeringer C, Su D, Wang W, Wu P, Moffat JG, Heffron TP, Choo EF, Chan BK. Tellis JC, et al. Among authors: chen y. ACS Med Chem Lett. 2024 Sep 3;15(9):1606-1614. doi: 10.1021/acsmedchemlett.4c00319. eCollection 2024 Sep 12. ACS Med Chem Lett. 2024. PMID: 39291002
178,868 results
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