Chen J - Search Results

1

Discovery of Novel Oleamide Analogues as Brain-Penetrant Positive Allosteric Serotonin 5-HT_2C Receptor and Dual 5-HT_2C/5-HT_2A Receptor Modulators.

Chen J, Garcia EJ, Merritt CR, Zamora JC, Bolinger AA, Pazdrak K, Stafford SJ, Mifflin RC, Wold EA, Wild CT, Chen H, Anastasio NC, Cunningham KA, Zhou J. Chen J, et al. Among authors: chen h. J Med Chem. 2023 Jul 27;66(14):9992-10009. doi: 10.1021/acs.jmedchem.3c00908. Epub 2023 Jul 18. J Med Chem. 2023. PMID: 37462530 Free PMC article.

2

Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts.

Wold EA, Chen J, Cunningham KA, Zhou J. Wold EA, et al. Among authors: chen j. J Med Chem. 2019 Jan 10;62(1):88-127. doi: 10.1021/acs.jmedchem.8b00875. Epub 2018 Aug 28. J Med Chem. 2019. PMID: 30106578 Free PMC article. Review.

3

Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT_2C Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties.

Wold EA, Garcia EJ, Wild CT, Miszkiel JM, Soto CA, Chen J, Pazdrak K, Fox RG, Anastasio NC, Cunningham KA, Zhou J. Wold EA, et al. Among authors: chen j. J Med Chem. 2020 Jul 23;63(14):7529-7544. doi: 10.1021/acs.jmedchem.9b01953. Epub 2020 Jul 7. J Med Chem. 2020. PMID: 32567857 Free PMC article.

4

Discovery of phenanthridine analogues as novel chemical probes disrupting the binding of DNA to ΔFosB homodimers and ΔFosB/JunD heterodimers.

Li Y, Liu Z, Aglyamova G, Chen J, Chen H, Bhandari M, White MA, Rudenko G, Zhou J. Li Y, et al. Among authors: chen j, chen h. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127300. doi: 10.1016/j.bmcl.2020.127300. Epub 2020 Jun 6. Bioorg Med Chem Lett. 2020. PMID: 32631520 Free PMC article.

5

Embryonic Ectoderm Development (EED) as a Novel Target for Cancer Treatment.

Cook N, Chen J, Zhou J, Wu D. Cook N, et al. Among authors: chen j. Curr Top Med Chem. 2021;21(31):2771-2777. doi: 10.2174/1568026621666210920154942. Curr Top Med Chem. 2021. PMID: 34544341 Review.

6

Target-Based Small Molecule Drug Discovery Towards Novel Therapeutics for Inflammatory Bowel Diseases.

Li Y, Chen J, Bolinger AA, Chen H, Liu Z, Cong Y, Brasier AR, Pinchuk IV, Tian B, Zhou J. Li Y, et al. Among authors: chen j, chen h. Inflamm Bowel Dis. 2021 Nov 15;27(Suppl 2):S38-S62. doi: 10.1093/ibd/izab190. Inflamm Bowel Dis. 2021. PMID: 34791293 Review.

7

Chemically targeting the redox switch in AP1 transcription factor ΔFOSB.

Kumar A, Aglyamova G, Yim YY, Bailey AO, Lynch HM, Powell RT, Nguyen ND, Rosenthal Z, Zhao WN, Li Y, Chen J, Fan S, Lee H, Russell WK, Stephan C, Robison AJ, Haggarty SJ, Nestler EJ, Zhou J, Machius M, Rudenko G. Kumar A, et al. Among authors: chen j. Nucleic Acids Res. 2022 Sep 9;50(16):9548-9567. doi: 10.1093/nar/gkac710. Nucleic Acids Res. 2022. PMID: 36039764 Free PMC article.

8

The efficacy of expanded non-invasive prenatal testing (NIPT) in a high-risk twin pregnancies cohort.

Meng M, Chen J, Yang Y, Zhang Y, Zou G, Zhou F, Wei X, Ge Y, Zhou J, Sun L. Meng M, et al. Among authors: chen j. Acta Obstet Gynecol Scand. 2024 Dec;103(12):2426-2432. doi: 10.1111/aogs.14958. Epub 2024 Oct 2. Acta Obstet Gynecol Scand. 2024. PMID: 39356042 Free PMC article.

9

An Investigation of the Etiologies of Non-Immune Hydrops Fetalis in the Era of Next-Generation Sequence-A Single Center Experience.

Wei X, Yang Y, Zhou J, Zhou X, Xiong S, Chen J, Zhou F, Zou G, Sun L. Wei X, et al. Among authors: chen j. Genes (Basel). 2022 Nov 28;13(12):2231. doi: 10.3390/genes13122231. Genes (Basel). 2022. PMID: 36553497 Free PMC article.

10

Unveiling the role of OsSAP17: Enhancing plant resistance to drought and salt.

Jiang W, Shi Y, Du Z, Zhou Y, Wu L, Chen J, Huang Y, Wu L, Liang Y, Zhang Z, Kumar V, Chen Z, Li D, Huang J. Jiang W, et al. Among authors: chen j. Plant Physiol Biochem. 2024 Dec 28;220:109451. doi: 10.1016/j.plaphy.2024.109451. Online ahead of print. Plant Physiol Biochem. 2024. PMID: 39854789

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