Wild CT - Search Results

1

Discovery of Novel Oleamide Analogues as Brain-Penetrant Positive Allosteric Serotonin 5-HT_2C Receptor and Dual 5-HT_2C/5-HT_2A Receptor Modulators.

Chen J, Garcia EJ, Merritt CR, Zamora JC, Bolinger AA, Pazdrak K, Stafford SJ, Mifflin RC, Wold EA, Wild CT, Chen H, Anastasio NC, Cunningham KA, Zhou J. Chen J, et al. Among authors: wild ct. J Med Chem. 2023 Jul 27;66(14):9992-10009. doi: 10.1021/acs.jmedchem.3c00908. Epub 2023 Jul 18. J Med Chem. 2023. PMID: 37462530 Free PMC article.

2

Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT_2C Receptor.

Wild CT, Miszkiel JM, Wold EA, Soto CA, Ding C, Hartley RM, White MA, Anastasio NC, Cunningham KA, Zhou J. Wild CT, et al. J Med Chem. 2019 Jan 10;62(1):288-305. doi: 10.1021/acs.jmedchem.8b00401. Epub 2018 Apr 13. J Med Chem. 2019. PMID: 29620897 Free PMC article.

3

Targeting the 5-HT2C Receptor in Biological Context and the Current State of 5-HT2C Receptor Ligand Development.

Wold EA, Wild CT, Cunningham KA, Zhou J. Wold EA, et al. Among authors: wild ct. Curr Top Med Chem. 2019;19(16):1381-1398. doi: 10.2174/1568026619666190709101449. Curr Top Med Chem. 2019. PMID: 31288724 Free PMC article. Review.

4

GPCR Drug Discovery: Emerging Targets, Novel Approaches and Future Trends.

Zhou J, Wild C. Zhou J, et al. Curr Top Med Chem. 2019;19(16):1363-1364. doi: 10.2174/156802661916190828093500. Curr Top Med Chem. 2019. PMID: 31513505 Free PMC article.

5

Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT_2C Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties.

Wold EA, Garcia EJ, Wild CT, Miszkiel JM, Soto CA, Chen J, Pazdrak K, Fox RG, Anastasio NC, Cunningham KA, Zhou J. Wold EA, et al. Among authors: wild ct. J Med Chem. 2020 Jul 23;63(14):7529-7544. doi: 10.1021/acs.jmedchem.9b01953. Epub 2020 Jul 7. J Med Chem. 2020. PMID: 32567857 Free PMC article.

6

Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.

Ye N, Zhu Y, Chen H, Liu Z, Mei FC, Wild C, Chen H, Cheng X, Zhou J. Ye N, et al. J Med Chem. 2015 Aug 13;58(15):6033-47. doi: 10.1021/acs.jmedchem.5b00635. Epub 2015 Jul 16. J Med Chem. 2015. PMID: 26151319 Free PMC article.

7

Allosteric Modulation of G Protein-Coupled Receptors: An Emerging Approach of Drug Discovery.

Wild C, Cunningham KA, Zhou J. Wild C, et al. Austin J Pharmacol Ther. 2014;2(1):1101. Epub 2014 Feb 27. Austin J Pharmacol Ther. 2014. PMID: 27148592 Free PMC article.

8

Functionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors.

Wild CT, Zhu Y, Na Y, Mei F, Ynalvez MA, Chen H, Cheng X, Zhou J. Wild CT, et al. ACS Med Chem Lett. 2016 Mar 28;7(5):460-4. doi: 10.1021/acsmedchemlett.5b00477. eCollection 2016 May 12. ACS Med Chem Lett. 2016. PMID: 27190593 Free PMC article.

9

Discovery and development of natural product oridonin-inspired anticancer agents.

Ding Y, Ding C, Ye N, Liu Z, Wold EA, Chen H, Wild C, Shen Q, Zhou J. Ding Y, et al. Eur J Med Chem. 2016 Oct 21;122:102-117. doi: 10.1016/j.ejmech.2016.06.015. Epub 2016 Jun 13. Eur J Med Chem. 2016. PMID: 27344488 Free PMC article. Review.

10

Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility.

Ding C, Zhang Y, Chen H, Yang Z, Wild C, Chu L, Liu H, Shen Q, Zhou J. Ding C, et al. J Med Chem. 2013 Jun 27;56(12):5048-58. doi: 10.1021/jm400367n. Epub 2013 Jun 19. J Med Chem. 2013. PMID: 23746196 Free PMC article.

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