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An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs.
Chapple RH, Liu X, Natarajan S, Alexander MIM, Kim Y, Patel AG, LaFlamme CW, Pan M, Wright WC, Lee HM, Zhang Y, Lu M, Koo SC, Long C, Harper J, Savage C, Johnson MD, Confer T, Akers WJ, Dyer MA, Sheppard H, Easton J, Geeleher P. Chapple RH, et al. Among authors: sheppard h. Genome Biol. 2024 Jun 19;25(1):161. doi: 10.1186/s13059-024-03309-4. Genome Biol. 2024. PMID: 38898465 Free PMC article.
CD47 expression is critical for CAR T-cell survival in vivo.
Beckett AN, Chockley P, Pruett-Miller SM, Nguyen P, Vogel P, Sheppard H, Krenciute G, Gottschalk S, DeRenzo C. Beckett AN, et al. Among authors: sheppard h. J Immunother Cancer. 2023 Mar;11(3):e005857. doi: 10.1136/jitc-2022-005857. J Immunother Cancer. 2023. PMID: 36918226 Free PMC article.
Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma.
Fang J, Singh S, Cheng C, Natarajan S, Sheppard H, Abu-Zaid A, Durbin AD, Lee HW, Wu Q, Steele J, Connelly JP, Jin H, Chen W, Fan Y, Pruett-Miller SM, Rehg JE, Koo SC, Santiago T, Emmons J, Cairo S, Wang R, Glazer ES, Murphy AJ, Chen T, Davidoff AM, Armengol C, Easton J, Chen X, Yang J. Fang J, et al. Among authors: sheppard h. Nat Commun. 2023 Jul 6;14(1):4003. doi: 10.1038/s41467-023-39717-6. Nat Commun. 2023. PMID: 37414763 Free PMC article.
AAV-mediated gene therapy for sialidosis.
van de Vlekkert D, Hu H, Weesner JA, Fremuth LE, Brown SA, Lu M, Gomero E, Campos Y, Sheppard H, d'Azzo A. van de Vlekkert D, et al. Among authors: sheppard h. Mol Ther. 2024 Jul 3;32(7):2094-2112. doi: 10.1016/j.ymthe.2024.05.029. Epub 2024 May 25. Mol Ther. 2024. PMID: 38796704 Free article.
Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma.
Wang T, Liu L, Fang J, Jin H, Natarajan S, Sheppard H, Lu M, Turner G, Confer T, Johnson M, Steinberg J, Ha L, Yadak N, Jain R, Picketts DJ, Ma X, Murphy A, Davidoff AM, Glazer ES, Easton J, Chen X, Wang R, Yang J. Wang T, et al. Among authors: sheppard h. Cancer Res. 2024 Nov 12. doi: 10.1158/0008-5472.CAN-24-1142. Online ahead of print. Cancer Res. 2024. PMID: 39531507
Ancestral β-globin gene haplotypes modify β-thalassemia severity in a mouse model.
Lechauve C, Keith J, Dudley MW, Fernandez AG, Khandros E, Mayberry K, Mayuranathan T, Palmer L, Qiu X, Sheppard H, Telange R, Herz HM, Weiss MJ. Lechauve C, et al. Among authors: sheppard h. Blood Adv. 2024 Dec 10;8(23):5988-5992. doi: 10.1182/bloodadvances.2024012681. Blood Adv. 2024. PMID: 38536944 Free PMC article. No abstract available.
Modular chimeric cytokine receptors with leucine zippers enhance the antitumour activity of CAR T cells via JAK/STAT signalling.
Bell M, Lange S, Sejdiu BI, Ibanez J, Shi H, Sun X, Meng X, Nguyen P, Sutton M, Wagner J, Kc A, Langfitt D, Patil SL, Tan H, Pandey RV, Li Y, Yuan ZF, Anido AA, Ho M, Sheppard H, Vogel P, Yu J, Peng J, Chi H, Babu MM, Krenciute G, Gottschalk S. Bell M, et al. Among authors: sheppard h. Nat Biomed Eng. 2024 Apr;8(4):380-396. doi: 10.1038/s41551-023-01143-w. Epub 2023 Nov 30. Nat Biomed Eng. 2024. PMID: 38036617 Free PMC article.
291 results