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Pilot clinical trial and phenotypic analysis in chemotherapy-pretreated, metastatic triple-negative breast cancer patients treated with oral TAK-228 and TAK-117 (PIKTOR) to increase DNA damage repair deficiency followed by cisplatin and nab paclitaxel.
Lang JD, Nguyen TVV, Levin MK, Blas PE, Williams HL, Rodriguez ESR, Briones N, Mueller C, Selleck W, Moore S, Zismann VL, Hendricks WPD, Espina V, O'Shaughnessy J. Lang JD, et al. Among authors: rodriguez esr. Biomark Res. 2023 Jul 25;11(1):73. doi: 10.1186/s40364-023-00511-7. Biomark Res. 2023. PMID: 37491309 Free PMC article.
Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer.
Ghergurovich JM, Lang JD, Levin MK, Briones N, Facista SJ, Mueller C, Cowan AJ, McBride MJ, Rodriguez ESR, Killian A, Dao T, Lamont J, Barron A, Su X, Hendricks WPD, Espina V, Von Hoff DD, O'Shaughnessy J, Rabinowitz JD. Ghergurovich JM, et al. Among authors: rodriguez esr. Med. 2021 Jun 11;2(6):736-754. doi: 10.1016/j.medj.2021.03.009. Epub 2021 Apr 14. Med. 2021. PMID: 34223403 Free PMC article. Clinical Trial.