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Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute.
Vargas HM, Rossman EI, Wisialowski TA, Nichols J, Pugsley MK, Roche B, Gintant GA, Greiter-Wilke A, Kleiman RB, Valentin JP, Leishman DJ. Vargas HM, et al. Among authors: leishman dj. J Pharmacol Toxicol Methods. 2023 May-Jun;121:107265. doi: 10.1016/j.vascn.2023.107265. Epub 2023 Mar 28. J Pharmacol Toxicol Methods. 2023. PMID: 36997076 Free article. Review.
Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment.
Wisialowski TA, Ether N, Foley CM, Kleiman R, Koshman Y, Leishman D, Martel E, Nichols JV, Popp J, Rajamani S, Riley S, Rossman EI, Vargas HM. Wisialowski TA, et al. J Pharmacol Toxicol Methods. 2024 Jul-Aug;128:107515. doi: 10.1016/j.vascn.2024.107515. Epub 2024 May 20. J Pharmacol Toxicol Methods. 2024. PMID: 38777240 Free article. No abstract available.
Assessment of corrected JT-peak (JTpc) and Tpeak-to-Tend (TpTec) as proarrhythmia biomarkers in non-human primates: Outcome from a HESI consortium.
Boulay E, Authier S, Bartko T, Greiter-Wilke A, Leishman D, Li D, Nichols JV, Pierson J, Rossman EI, Valentin JP, Vicente J, Walisser J, Troncy E, Wisialowski TA. Boulay E, et al. J Pharmacol Toxicol Methods. 2024 Sep-Oct;129:107543. doi: 10.1016/j.vascn.2024.107543. Epub 2024 Jul 15. J Pharmacol Toxicol Methods. 2024. PMID: 39019200
60 results