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LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling.
Schelker RC, Fioravanti J, Mastrogiovanni F, Baldwin JG, Rana N, Li P, Chen P, Vadász T, Spolski R, Heuser-Loy C, Slavkovic-Lukic D, Noronha P, Damiano G, Raccosta L, Maggioni D, Pullugula S, Lin JX, Oh J, Grandinetti P, Lecce M, Hesse L, Kocks E, Martín-Santos A, Gebhard C, Telford WG, Ji Y, Restifo NP, Russo V, Rehli M, Herr W, Leonard WJ, Gattinoni L. Schelker RC, et al. Among authors: li p. Signal Transduct Target Ther. 2024 Aug 9;9(1):199. doi: 10.1038/s41392-024-01915-z. Signal Transduct Target Ther. 2024. PMID: 39117617 Free PMC article.
Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity.
Leonard EK, Tomala J, Gould JR, Leff MI, Lin JX, Li P, Porter MJ, Johansen ER, Thompson L, Cao SD, Hou S, Henclova T, Huliciak M, Sargunas PR, Fabilane CS, Vaněk O, Kovar M, Schneider B, Raimondi G, Leonard WJ, Spangler JB. Leonard EK, et al. Among authors: li p. JCI Insight. 2024 Sep 24;9(18):e173469. doi: 10.1172/jci.insight.173469. JCI Insight. 2024. PMID: 39115939 Free PMC article.
Intestinal epithelial cell NCoR deficiency ameliorates obesity and metabolic syndrome.
Hou S, Yu H, Liu C, Johnson AMF, Liu X, Jiang Q, Zhao Q, Kong L, Wan Y, Xing X, Chen Y, Chen J, Wu Q, Zhang P, Jiang C, Cui B, Li P. Hou S, et al. Among authors: li p. Acta Pharm Sin B. 2024 Dec;14(12):5267-5285. doi: 10.1016/j.apsb.2024.09.019. Epub 2024 Oct 10. Acta Pharm Sin B. 2024. PMID: 39807334 Free PMC article.
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