Niimi T - Search Results

1

Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro, and X-ray Crystallography.

Yoshino R, Yasuo N, Hagiwara Y, Ishida T, Inaoka DK, Amano Y, Tateishi Y, Ohno K, Namatame I, Niimi T, Orita M, Kita K, Akiyama Y, Sekijima M. Yoshino R, et al. Among authors: niimi t. ACS Omega. 2023 Jul 12;8(29):25850-25860. doi: 10.1021/acsomega.3c01314. eCollection 2023 Jul 25. ACS Omega. 2023. PMID: 37521650 Free PMC article.

2

In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease.

Yoshino R, Yasuo N, Hagiwara Y, Ishida T, Inaoka DK, Amano Y, Tateishi Y, Ohno K, Namatame I, Niimi T, Orita M, Kita K, Akiyama Y, Sekijima M. Yoshino R, et al. Among authors: niimi t. Sci Rep. 2017 Jul 27;7(1):6666. doi: 10.1038/s41598-017-06411-9. Sci Rep. 2017. PMID: 28751689 Free PMC article.

3

Two 'Golden Ratio' indices in fragment-based drug discovery.

Orita M, Ohno K, Niimi T. Orita M, et al. Among authors: niimi t. Drug Discov Today. 2009 Mar;14(5-6):321-8. doi: 10.1016/j.drudis.2008.10.006. Epub 2008 Dec 10. Drug Discov Today. 2009. PMID: 19028598 Review.

4

Advances in fragment-based drug discovery platforms.

Orita M, Warizaya M, Amano Y, Ohno K, Niimi T. Orita M, et al. Among authors: niimi t. Expert Opin Drug Discov. 2009 Nov;4(11):1125-44. doi: 10.1517/17460440903317580. Expert Opin Drug Discov. 2009. PMID: 23480433

5

Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase.

Amano Y, Namatame I, Tateishi Y, Honboh K, Tanabe E, Niimi T, Sakashita H. Amano Y, et al. Among authors: niimi t. Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1879-89. doi: 10.1107/S1399004715013048. Epub 2015 Aug 25. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26327378

6

An NMR Biochemical Assay for Fragment-Based Drug Discovery: Evaluation of an Inhibitor Activity on Spermidine Synthase of Trypanosoma cruzi.

Yamasaki K, Tani O, Tateishi Y, Tanabe E, Namatame I, Niimi T, Furukawa K, Sakashita H. Yamasaki K, et al. Among authors: niimi t. J Med Chem. 2016 Mar 10;59(5):2261-6. doi: 10.1021/acs.jmedchem.5b01769. Epub 2016 Feb 29. J Med Chem. 2016. PMID: 26881725

7

Small-world phenomena in chemical library networks: application to fragment-based drug discovery.

Tanaka N, Ohno K, Niimi T, Moritomo A, Mori K, Orita M. Tanaka N, et al. Among authors: niimi t. J Chem Inf Model. 2009 Dec;49(12):2677-86. doi: 10.1021/ci900123v. J Chem Inf Model. 2009. PMID: 19961207

8

Use of Benford's law in drug discovery data.

Orita M, Moritomo A, Niimi T, Ohno K. Orita M, et al. Among authors: niimi t. Drug Discov Today. 2010 May;15(9-10):328-31. doi: 10.1016/j.drudis.2010.03.003. Epub 2010 Mar 16. Drug Discov Today. 2010. PMID: 20298800

9

Docking study and binding free energy calculation of poly (ADP-ribose) polymerase inhibitors.

Ohno K, Mitsui T, Tanida Y, Matsuura A, Fujitani H, Niimi T, Orita M. Ohno K, et al. Among authors: niimi t. J Mol Model. 2011 Feb;17(2):383-9. doi: 10.1007/s00894-010-0728-2. Epub 2010 May 18. J Mol Model. 2011. PMID: 20480380

10

Lead generation and examples opinion regarding how to follow up hits.

Orita M, Ohno K, Warizaya M, Amano Y, Niimi T. Orita M, et al. Among authors: niimi t. Methods Enzymol. 2011;493:383-419. doi: 10.1016/B978-0-12-381274-2.00015-7. Methods Enzymol. 2011. PMID: 21371599

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