Hettle A - Search Results

1

A Fluorogenic Disaccharide Substrate for α-Mannosidases Enables High-Throughput Screening and Identification of an Inhibitor of the GH92 Virulence Factor from Streptococcus pneumoniae.

Bhosale S, Deen MC, Proceviat C, Hettle A, Winter DK, Brockerman J, Levene M, Bennet AJ, Spino C, Boraston AB, Vocadlo DJ. Bhosale S, et al. Among authors: hettle a. ACS Chem Biol. 2023 Aug 18;18(8):1730-1737. doi: 10.1021/acschembio.3c00053. Epub 2023 Aug 2. ACS Chem Biol. 2023. PMID: 37531094

2

Sulfatases: Critical Enzymes for Algal Polysaccharide Processing.

Hettle AG, Vickers CJ, Boraston AB. Hettle AG, et al. Front Plant Sci. 2022 Apr 28;13:837636. doi: 10.3389/fpls.2022.837636. eCollection 2022. Front Plant Sci. 2022. PMID: 35574087 Free PMC article. Review.

3

Metabolism of a hybrid algal galactan by members of the human gut microbiome.

Robb CS, Hobbs JK, Pluvinage B, Reintjes G, Klassen L, Monteith S, Giljan G, Amundsen C, Vickers C, Hettle AG, Hills R, Nitin, Xing X, Montina T, Zandberg WF, Abbott DW, Boraston AB. Robb CS, et al. Among authors: hettle ag. Nat Chem Biol. 2022 May;18(5):501-510. doi: 10.1038/s41589-022-00983-y. Epub 2022 Mar 14. Nat Chem Biol. 2022. PMID: 35289327

4

The structure of a family 110 glycoside hydrolase provides insight into the hydrolysis of α-1,3-galactosidic linkages in λ-carrageenan and blood group antigens.

McGuire BE, Hettle AG, Vickers C, King DT, Vocadlo DJ, Boraston AB. McGuire BE, et al. Among authors: hettle ag. J Biol Chem. 2020 Dec 25;295(52):18426-18435. doi: 10.1074/jbc.RA120.015776. Epub 2020 Oct 30. J Biol Chem. 2020. PMID: 33127644 Free PMC article.

5

Insights into the κ/ι-carrageenan metabolism pathway of some marine Pseudoalteromonas species.

Hettle AG, Hobbs JK, Pluvinage B, Vickers C, Abe KT, Salama-Alber O, McGuire BE, Hehemann JH, Hui JPM, Berrue F, Banskota A, Zhang J, Bottos EM, Van Hamme J, Boraston AB. Hettle AG, et al. Commun Biol. 2019 Dec 19;2:474. doi: 10.1038/s42003-019-0721-y. eCollection 2019. Commun Biol. 2019. PMID: 31886414 Free PMC article.

6

Clinical Mutations That Partially Activate the Stringent Response Confer Multidrug Tolerance in Staphylococcus aureus.

Bryson D, Hettle AG, Boraston AB, Hobbs JK. Bryson D, et al. Among authors: hettle ag. Antimicrob Agents Chemother. 2020 Feb 21;64(3):e02103-19. doi: 10.1128/AAC.02103-19. Print 2020 Feb 21. Antimicrob Agents Chemother. 2020. PMID: 31871080 Free PMC article.

7

Biochemical Reconstruction of a Metabolic Pathway from a Marine Bacterium Reveals Its Mechanism of Pectin Depolymerization.

Hobbs JK, Hettle AG, Vickers C, Boraston AB. Hobbs JK, et al. Among authors: hettle ag. Appl Environ Microbiol. 2018 Dec 13;85(1):e02114-18. doi: 10.1128/AEM.02114-18. Print 2019 Jan 1. Appl Environ Microbiol. 2018. PMID: 30341080 Free PMC article.

8

The Molecular Basis of Polysaccharide Sulfatase Activity and a Nomenclature for Catalytic Subsites in this Class of Enzyme.

Hettle AG, Vickers C, Robb CS, Liu F, Withers SG, Hehemann JH, Boraston AB. Hettle AG, et al. Structure. 2018 May 1;26(5):747-758.e4. doi: 10.1016/j.str.2018.03.012. Epub 2018 Apr 19. Structure. 2018. PMID: 29681469 Free article.

9

Properties of a family 56 carbohydrate-binding module and its role in the recognition and hydrolysis of β-1,3-glucan.

Hettle A, Fillo A, Abe K, Massel P, Pluvinage B, Langelaan DN, Smith SP, Boraston AB. Hettle A, et al. J Biol Chem. 2017 Oct 13;292(41):16955-16968. doi: 10.1074/jbc.M117.806711. Epub 2017 Aug 21. J Biol Chem. 2017. PMID: 28827308 Free PMC article.

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