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Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy.
Chen GM, Chen C, Das RK, Gao P, Chen CH, Bandyopadhyay S, Ding YY, Uzun Y, Yu W, Zhu Q, Myers RM, Grupp SA, Barrett DM, Tan K. Chen GM, et al. Among authors: yu w. Cancer Discov. 2021 Sep;11(9):2186-2199. doi: 10.1158/2159-8290.CD-20-1677. Epub 2021 Apr 5. Cancer Discov. 2021. PMID: 33820778 Free PMC article. Clinical Trial.
RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils.
Zezulin AU, Ye D, Howell E, Yen D, Bresciani E, Diemer J, Ren JG, Ahmad MH, Castilla LH, Touw IP, Minn AJ, Tong W, Liu PP, Tan K, Yu W, Speck NA. Zezulin AU, et al. Among authors: yu w. bioRxiv [Preprint]. 2023 Jan 28:2023.01.27.525911. doi: 10.1101/2023.01.27.525911. bioRxiv. 2023. Update in: Genes Dev. 2023 Jul 1;37(13-14):605-620. doi: 10.1101/gad.350418.123 PMID: 36747636 Free PMC article. Updated. Preprint.
Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia.
Chen C, Yu W, Alikarami F, Qiu Q, Chen CH, Flournoy J, Gao P, Uzun Y, Fang L, Davenport JW, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding YY, Hunger SP, Felix CA, Wu H, Brown PA, Guest EM, Barrett DM, Bernt KM, Tan K. Chen C, et al. Among authors: yu w. Blood. 2022 Apr 7;139(14):2198-2211. doi: 10.1182/blood.2021013442. Blood. 2022. PMID: 34864916 Free PMC article.
Identification and targeting of treatment resistant progenitor populations in T-cell Acute Lymphoblastic Leukemia.
Tan K, Xu J, Chen C, Vincent T, Pölönen P, Hu J, Yoshimura S, Yu W, Sussman J, Chen CH, Li E, Diorio C, Shraim R, Newman H, Uppuluri L, Li A, Chen G, Bandyopadhyay S, Wu D, Ding YY, Xu J, Lim T, Hsu M, Thadi A, Ahn KJ, Wu CY, Peng J, Sun Y, Wang A, Mehta R, Frank D, Meyer L, Loh M, Raetz E, Chen Z, Wood B, Devidas M, Dunsmore K, Winter S, Chang TC, Wu G, Pounds S, Zhang N, Carroll W, Hunger S, Bernt K, Yang J, Mullighan C, Teachey D. Tan K, et al. Among authors: yu w. Res Sq [Preprint]. 2023 Oct 30:rs.3.rs-3487715. doi: 10.21203/rs.3.rs-3487715/v1. Res Sq. 2023. Update in: Nat Cancer. 2024 Nov 25. doi: 10.1038/s43018-024-00863-5 PMID: 37961674 Free PMC article. Updated. Preprint.
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