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Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes.
Spanier JA, Fung V, Wardell CM, Alkhatib MH, Chen Y, Swanson LA, Dwyer AJ, Weno ME, Silva N, Mitchell JS, Orban PC, Mojibian M, Verchere CB, Fife BT, Levings MK. Spanier JA, et al. Among authors: alkhatib mh. bioRxiv [Preprint]. 2023 Feb 24:2023.02.23.529737. doi: 10.1101/2023.02.23.529737. bioRxiv. 2023. Update in: J Clin Invest. 2023 Sep 15;133(18):e168601. doi: 10.1172/JCI168601 PMID: 36865264 Free PMC article. Updated. Preprint.
CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes.
Mitchell JS, Spanier JA, Dwyer AJ, Knutson TP, Alkhatib MH, Qian G, Weno ME, Chen Y, Shaheen ZR, Tucker CG, Kangas TO, Morales MS, Silva N, Kaisho T, Farrar MA, Fife BT. Mitchell JS, et al. Among authors: alkhatib mh. Immunity. 2024 Oct 8;57(10):2399-2415.e8. doi: 10.1016/j.immuni.2024.07.024. Epub 2024 Aug 29. Immunity. 2024. PMID: 39214091
18 results