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Page 1
Associations Between Cancer Predisposition Mutations and Clonal Hematopoiesis in Patients With Solid Tumors.
Franch-Expósito S, Mehine M, Ptashkin RN, Bolton KL, Bandlamudi C, Srinivasan P, Zhang L, Goodell MA, Gedvilaite E, Menghrajani K, Sánchez-Vela P, Mandelker D, Comen E, Norton L, Benayed R, Gao T, Papaemmanuil E, Taylor B, Levine R, Offit K, Stadler Z, Berger MF, Zehir A. Franch-Expósito S, et al. Among authors: mehine m. JCO Precis Oncol. 2023 Aug;7:e2300070. doi: 10.1200/PO.23.00070. JCO Precis Oncol. 2023. PMID: 37561983 Free PMC article.
NBN Pathogenic Germline Variants are Associated with Pan-Cancer Susceptibility and In Vitro DNA Damage Response Defects.
Belhadj S, Khurram A, Bandlamudi C, Palou-Márquez G, Ravichandran V, Steinsnyder Z, Wildman T, Catchings A, Kemel Y, Mukherjee S, Fesko B, Arora K, Mehine M, Dandiker S, Izhar A, Petrini J, Domchek S, Nathanson KL, Brower J, Couch F, Stadler Z, Robson M, Walsh M, Vijai J, Berger M, Supek F, Karam R, Topka S, Offit K. Belhadj S, et al. Among authors: mehine m. Clin Cancer Res. 2023 Jan 17;29(2):422-431. doi: 10.1158/1078-0432.CCR-22-1703. Clin Cancer Res. 2023. PMID: 36346689 Free PMC article.
Genetic Ancestry Correlates with Somatic Differences in a Real-World Clinical Cancer Sequencing Cohort.
Arora K, Tran TN, Kemel Y, Mehine M, Liu YL, Nandakumar S, Smith SA, Brannon AR, Ostrovnaya I, Stopsack KH, Razavi P, Safonov A, Rizvi HA, Hellmann MD, Vijai J, Reynolds TC, Fagin JA, Carrot-Zhang J, Offit K, Solit DB, Ladanyi M, Schultz N, Zehir A, Brown CL, Stadler ZK, Chakravarty D, Bandlamudi C, Berger MF. Arora K, et al. Among authors: mehine m. Cancer Discov. 2022 Nov 2;12(11):2552-2565. doi: 10.1158/2159-8290.CD-22-0312. Cancer Discov. 2022. PMID: 36048199 Free PMC article.
Methylation Analyses Reveal Promoter Hypermethylation as a Rare Cause of "Second Hit" in Germline BRCA1-Associated Pancreatic Ductal Adenocarcinoma.
Zheng-Lin B, Rainone M, Varghese AM, Yu KH, Park W, Berger M, Mehine M, Chou J, Capanu M, Mandelker D, Stadler ZK, Birsoy O, Jairam S, Yang C, Li Y, Wong D, Benhamida JK, Ladanyi M, Zhang L, O'Reilly EM. Zheng-Lin B, et al. Among authors: mehine m. Mol Diagn Ther. 2022 Nov;26(6):645-653. doi: 10.1007/s40291-022-00614-1. Epub 2022 Sep 30. Mol Diagn Ther. 2022. PMID: 36178671 Free PMC article.
Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.
Kämpjärvi K, Mäkinen N, Kilpivaara O, Arola J, Heinonen HR, Böhm J, Abdel-Wahab O, Lehtonen HJ, Pelttari LM, Mehine M, Schrewe H, Nevanlinna H, Levine RL, Hokland P, Böhling T, Mecklin JP, Bützow R, Aaltonen LA, Vahteristo P. Kämpjärvi K, et al. Among authors: mehine m. Br J Cancer. 2012 Nov 6;107(10):1761-5. doi: 10.1038/bjc.2012.428. Epub 2012 Sep 20. Br J Cancer. 2012. PMID: 23132392 Free PMC article.
MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas.
Kämpjärvi K, Mäkinen N, Mehine M, Välipakka S, Uimari O, Pitkänen E, Heinonen HR, Heikkinen T, Tolvanen J, Ahtikoski A, Frizzell N, Sarvilinna N, Sjöberg J, Bützow R, Aaltonen LA, Vahteristo P. Kämpjärvi K, et al. Among authors: mehine m. Br J Cancer. 2016 Jun 14;114(12):1405-11. doi: 10.1038/bjc.2016.130. Epub 2016 May 17. Br J Cancer. 2016. PMID: 27187686 Free PMC article.
Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas.
Kämpjärvi K, Park MJ, Mehine M, Kim NH, Clark AD, Bützow R, Böhling T, Böhm J, Mecklin JP, Järvinen H, Tomlinson IP, van der Spuy ZM, Sjöberg J, Boyer TG, Vahteristo P. Kämpjärvi K, et al. Among authors: mehine m. Hum Mutat. 2014 Sep;35(9):1136-41. doi: 10.1002/humu.22612. Epub 2014 Jul 21. Hum Mutat. 2014. PMID: 24980722
3'RNA and whole-genome sequencing of archival uterine leiomyomas reveal a tumor subtype with chromosomal rearrangements affecting either HMGA2, HMGA1, or PLAG1.
Jokinen V, Mehine M, Reinikka S, Khamaiseh S, Ahvenainen T, Äyräväinen A, Härkki P, Bützow R, Pasanen A, Vahteristo P. Jokinen V, et al. Among authors: mehine m. Genes Chromosomes Cancer. 2023 Jan;62(1):27-38. doi: 10.1002/gcc.23088. Epub 2022 Aug 1. Genes Chromosomes Cancer. 2023. PMID: 35822448 Free PMC article.
Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma.
Berta DG, Kuisma H, Välimäki N, Räisänen M, Jäntti M, Pasanen A, Karhu A, Kaukomaa J, Taira A, Cajuso T, Nieminen S, Penttinen RM, Ahonen S, Lehtonen R, Mehine M, Vahteristo P, Jalkanen J, Sahu B, Ravantti J, Mäkinen N, Rajamäki K, Palin K, Taipale J, Heikinheimo O, Bützow R, Kaasinen E, Aaltonen LA. Berta DG, et al. Among authors: mehine m. Nature. 2021 Aug;596(7872):398-403. doi: 10.1038/s41586-021-03747-1. Epub 2021 Aug 4. Nature. 2021. PMID: 34349258
32 results