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A germ-free humanized mouse model shows the contribution of resident microbiota to human-specific pathogen infection.
Wahl A, Yao W, Liao B, Chateau M, Richardson C, Ling L, Franks A, Senthil K, Doyon G, Li F, Frost J, Whitehurst CB, Pagano JS, Fletcher CA, Azcarate-Peril MA, Hudgens MG, Rogala AR, Tucker JD, McGowan I, Sartor RB, Garcia JV. Wahl A, et al. Among authors: sartor rb. Nat Biotechnol. 2024 Jun;42(6):905-915. doi: 10.1038/s41587-023-01906-5. Epub 2023 Aug 10. Nat Biotechnol. 2024. PMID: 37563299 Free PMC article.
Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.
Akhlaghpour M, Haritunians T, More SK, Thomas LS, Stamps DT, Dube S, Li D, Yang S, Landers CJ, Mengesha E, Hamade H, Murali R, Potdar AA, Wolf AJ, Botwin GJ, Khrom M; International IBD Genetics Consortium; Ananthakrishnan AN, Faubion WA, Jabri B, Lira SA, Newberry RD, Sandler RS, Sartor RB, Xavier RJ, Brant SR, Cho JH, Duerr RH, Lazarev MG, Rioux JD, Schumm LP, Silverberg MS, Zaghiyan K, Fleshner P, Melmed GY, Vasiliauskas EA, Ha C, Rabizadeh S, Syal G, Bonthala NN, Ziring DA, Targan SR, Long MD, McGovern DPB, Michelsen KS. Akhlaghpour M, et al. Among authors: sartor rb. Gut. 2023 Nov;72(11):2068-2080. doi: 10.1136/gutjnl-2023-329689. Epub 2023 Apr 20. Gut. 2023. PMID: 37080587 Free PMC article.
Bone loss with aging is independent of gut microbiome in mice.
You X, Yan J, Herzog J, Nobakhti S, Campbell R, Hoke A, Hammamieh R, Sartor RB, Shefelbine S, Kacena MA, Chakraborty N, Charles JF. You X, et al. Among authors: sartor rb. Bone Res. 2024 Nov 11;12(1):65. doi: 10.1038/s41413-024-00366-0. Bone Res. 2024. PMID: 39523344 Free PMC article.
Enhanced mucosal mitochondrial function corrects dysbiosis and OXPHOS metabolism in IBD.
Kapur N, Alam MA, Hassan SA, Patel PH, Wempe LA, Bhogoju S, Goretsky T, Kim JH, Herzog J, Ge Y, Awuah SG, Byndloss M, Baumler AJ, Zadeh MM, Sartor RB, Barrett T. Kapur N, et al. Among authors: sartor rb. bioRxiv [Preprint]. 2024 Mar 14:2024.03.14.584471. doi: 10.1101/2024.03.14.584471. bioRxiv. 2024. PMID: 38559035 Free PMC article. Preprint.
Comprehensive Association Analyses of Extraintestinal Manifestations in Inflammatory Bowel Disease.
Khrom M, Long M, Dube S, Robbins L, Botwin GJ, Yang S, Mengesha E, Li D, Naito T, Bonthala NN, Ha C, Melmed G, Rabizadeh S, Syal G, Vasiliauskas E, Ziring D, Brant SR, Cho J, Duerr RH, Rioux J, Schumm P, Silverberg M, Ananthakrishnan AN, Faubion WA, Jabri B, Lira SA, Newberry RD, Sandler RS, Xavier RJ, Kugathasan S, Hercules D, Targan SR, Sartor RB, Haritunians T, McGovern DPB. Khrom M, et al. Among authors: sartor rb. Gastroenterology. 2024 Jul;167(2):315-332. doi: 10.1053/j.gastro.2024.02.026. Epub 2024 Mar 13. Gastroenterology. 2024. PMID: 38490347
Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis.
Viladomiu M, Khounlotham M, Dogan B, Lima SF, Elsaadi A, Cardakli E, Castellanos JG, Ng C, Herzog J, Schoenborn AA, Ellermann M, Liu B, Zhang S, Gulati AS, Sartor RB, Simpson KW, Lipkin SM, Longman RS. Viladomiu M, et al. Among authors: sartor rb. Cell Rep. 2022 Nov 15;41(7):111637. doi: 10.1016/j.celrep.2022.111637. Cell Rep. 2022. PMID: 36384110 Free PMC article.
Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice.
Wolstenholme JT, Saunders JM, Smith M, Kang JD, Hylemon PB, González-Maeso J, Fagan A, Zhao D, Sikaroodi M, Herzog J, Shamsaddini A, Peña-Rodríguez M, Su L, Tai YL, Zheng J, Cheng PC, Sartor RB, Gillevet PM, Zhou H, Bajaj JS. Wolstenholme JT, et al. Among authors: sartor rb. Nat Commun. 2022 Oct 19;13(1):6198. doi: 10.1038/s41467-022-34054-6. Nat Commun. 2022. PMID: 36261423 Free PMC article. Clinical Trial.
302 results