Ma L - Search Results

1

Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator.

Rudd MT, Manley PJ, Hanney B, Meng Z, Shu Y, de Leon P, Frie JL, Han Y, Wai JM, Yang ZQ, Perkins JJ, Hurzy DM, Manikowski JJ, Zhu H, Bungard CJ, Converso A, Meissner RS, Cosden ML, Hayashi I, Ma L, O'Brien J, Uebele VN, Schachter JB, Bhandari N, Ward GJ, Fillgrove KL, Lu B, Liang Y, Dubost DC, Puri V, Eddins DM, Vardigan JD, Drolet RE, Kern JT, Uslaner JM. Rudd MT, et al. Among authors: ma l. ACS Med Chem Lett. 2023 Jul 12;14(8):1088-1094. doi: 10.1021/acsmedchemlett.3c00210. eCollection 2023 Aug 10. ACS Med Chem Lett. 2023. PMID: 37583812 Free PMC article.

2

Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators.

Yang FV, Shipe WD, Bunda JL, Nolt MB, Wisnoski DD, Zhao Z, Barrow JC, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Hartman GD, Lindsley CW. Yang FV, et al. Among authors: ma l. Bioorg Med Chem Lett. 2010 Jan 15;20(2):531-6. doi: 10.1016/j.bmcl.2009.11.100. Epub 2009 Nov 24. Bioorg Med Chem Lett. 2010. PMID: 20004574

3

N-heterocyclic derived M1 positive allosteric modulators.

Kuduk SD, Di Marco CN, Cofre V, Pitts DR, Ray WJ, Ma L, Wittmann M, Veng L, Seager MA, Koeplinger K, Thompson CD, Hartman GD, Bilodeau MT. Kuduk SD, et al. Among authors: ma l. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1334-7. doi: 10.1016/j.bmcl.2010.01.013. Epub 2010 Jan 11. Bioorg Med Chem Lett. 2010. PMID: 20097564

4

Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series.

Kuduk SD, Chang RK, Di Marco CN, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Kuduk SD, et al. Among authors: ma l. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1710-5. doi: 10.1016/j.bmcl.2011.01.094. Epub 2011 Jan 28. Bioorg Med Chem Lett. 2011. PMID: 21324684

5

Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold.

Kuduk SD, Chang RK, Di Marco CN, Pitts DR, Greshock TJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT, Ray WJ. Kuduk SD, et al. Among authors: ma l. J Med Chem. 2011 Jul 14;54(13):4773-80. doi: 10.1021/jm200400m. Epub 2011 Jun 17. J Med Chem. 2011. PMID: 21682298

6

Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M(1) positive allosteric modulators.

Kuduk SD, Di Marco CN, Saffold JR, Ray WJ, Ma L, Wittmann M, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT, Beshore DC. Kuduk SD, et al. Among authors: ma l. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1417-20. doi: 10.1016/j.bmcl.2014.01.012. Epub 2014 Jan 13. Bioorg Med Chem Lett. 2014. PMID: 24485781

7

Quinolizidinone carboxylic acids as CNS penetrant, selective m1 allosteric muscarinic receptor modulators.

Kuduk SD, Chang RK, Di Marco CN, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Kuduk SD, et al. Among authors: ma l. ACS Med Chem Lett. 2010 Jun 4;1(6):263-7. doi: 10.1021/ml100095k. eCollection 2010 Sep 9. ACS Med Chem Lett. 2010. PMID: 24900206 Free PMC article.

8

Identification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators.

Kuduk SD, Chang RK, Greshock TJ, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Kuduk SD, et al. Among authors: ma l. ACS Med Chem Lett. 2012 Oct 13;3(12):1070-4. doi: 10.1021/ml300280g. eCollection 2012 Dec 13. ACS Med Chem Lett. 2012. PMID: 24900430 Free PMC article.

9

Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators.

Yang ZQ, Shu Y, Ma L, Wittmann M, Ray WJ, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT, Kuduk SD. Yang ZQ, et al. Among authors: ma l. ACS Med Chem Lett. 2014 Feb 20;5(5):604-8. doi: 10.1021/ml500055h. eCollection 2014 May 8. ACS Med Chem Lett. 2014. PMID: 24900888 Free PMC article.

10

High-Throughput Agonist Shift Assay Development for the Analysis of M₁-Positive Allosteric Modulators.

Homsher MF, Beshore DC, Cassaday J, Squadroni B, Mohammed E, Hartnett M, Day S, Ma L, Pechter D, Smith MD, Monsma F, Zuck P, Finley MF, Uebele VN, Hermes JD. Homsher MF, et al. Among authors: ma l. SLAS Discov. 2017 Sep;22(8):1060-1066. doi: 10.1177/2472555217705373. Epub 2017 Apr 20. SLAS Discov. 2017. PMID: 28426939 Free article.

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