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Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition†Electronic supplementary information (ESI) available: Synthesis, cloning, protein expression, purification and biochemical assays. See DOI: 10.1039/c4sc02339k.
Kreuzer J, Bach NC, Forler D, Sieber SA. Kreuzer J, et al. Among authors: sieber sa. Chem Sci. 2014 Dec 1;6(1):237-245. doi: 10.1039/c4sc02339k. Epub 2014 Sep 26. Chem Sci. 2014. PMID: 25580214 Free PMC article.
The Natural Product Elegaphenone Potentiates Antibiotic Effects against Pseudomonas aeruginosa.
Zhao W, Cross AR, Crowe-McAuliffe C, Weigert-Munoz A, Csatary EE, Solinski AE, Krysiak J, Goldberg JB, Wilson DN, Medina E, Wuest WM, Sieber SA. Zhao W, et al. Among authors: sieber sa. Angew Chem Int Ed Engl. 2019 Jun 17;58(25):8581-8584. doi: 10.1002/anie.201903472. Epub 2019 May 16. Angew Chem Int Ed Engl. 2019. PMID: 30969469 Free PMC article.
Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms.
Le P, Kunold E, Macsics R, Rox K, Jennings MC, Ugur I, Reinecke M, Chaves-Moreno D, Hackl MW, Fetzer C, Mandl FAM, Lehmann J, Korotkov VS, Hacker SM, Kuster B, Antes I, Pieper DH, Rohde M, Wuest WM, Medina E, Sieber SA. Le P, et al. Among authors: sieber sa. Nat Chem. 2020 Feb;12(2):145-158. doi: 10.1038/s41557-019-0378-7. Epub 2019 Dec 16. Nat Chem. 2020. PMID: 31844194 Free PMC article.
197 results