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Glucocorticoids target the CXCL9/CXCL10-CXCR3 axis and confer protection against immune-mediated kidney injury.
Riedel JH, Robben L, Paust HJ, Zhao Y, Asada N, Song N, Peters A, Kaffke A, Borchers A, Tiegs G, Seifert L, Tomas NM, Hoxha E, Wenzel UO, Huber TB, Wiech T, Turner JE, Krebs CF, Panzer U. Riedel JH, et al. Among authors: seifert l. JCI Insight. 2023 Jan 10;8(1):e160251. doi: 10.1172/jci.insight.160251. JCI Insight. 2023. PMID: 36355429 Free PMC article.
The classical pathway triggers pathogenic complement activation in membranous nephropathy.
Seifert L, Zahner G, Meyer-Schwesinger C, Hickstein N, Dehde S, Wulf S, Köllner SMS, Lucas R, Kylies D, Froembling S, Zielinski S, Kretz O, Borodovsky A, Biniaminov S, Wang Y, Cheng H, Koch-Nolte F, Zipfel PF, Hopfer H, Puelles VG, Panzer U, Huber TB, Wiech T, Tomas NM. Seifert L, et al. Nat Commun. 2023 Jan 28;14(1):473. doi: 10.1038/s41467-023-36068-0. Nat Commun. 2023. PMID: 36709213 Free PMC article.
Autoantibodies Targeting Nephrin in Podocytopathies.
Hengel FE, Dehde S, Lassé M, Zahner G, Seifert L, Schnarre A, Kretz O, Demir F, Pinnschmidt HO, Grahammer F, Lucas R, Mehner LM, Zimmermann T, Billing AM, Oh J, Mitrotti A, Pontrelli P, Debiec H, Dossier C, Colucci M, Emma F, Smoyer WE, Weins A, Schaefer F, Alachkar N, Diemert A, Hogan J, Hoxha E, Wiech T, Rinschen MM, Ronco P, Vivarelli M, Gesualdo L, Tomas NM, Huber TB; International Society of Glomerular Disease. Hengel FE, et al. Among authors: seifert l. N Engl J Med. 2024 Aug 1;391(5):422-433. doi: 10.1056/NEJMoa2314471. Epub 2024 May 25. N Engl J Med. 2024. PMID: 38804512
291 results