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Cryo-EM visualizes multiple steps of dynein's activation pathway.
Kendrick AA, Nguyen KHV, Ma W, Karasmanis EP, Amaro RE, Reck-Peterson SL, Leschziner AE. Kendrick AA, et al. Among authors: karasmanis ep. bioRxiv [Preprint]. 2024 Oct 13:2024.09.28.615567. doi: 10.1101/2024.09.28.615567. bioRxiv. 2024. PMID: 39416051 Free PMC article. Preprint.
A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2.
Dederer V, Sanz Murillo M, Karasmanis EP, Hatch KS, Chatterjee D, Preuss F, Abdul Azeez KR, Nguyen LV, Galicia C, Dreier B, Plückthun A, Versees W, Mathea S, Leschziner AE, Reck-Peterson SL, Knapp S. Dederer V, et al. Among authors: karasmanis ep. J Biol Chem. 2024 Jul;300(7):107469. doi: 10.1016/j.jbc.2024.107469. Epub 2024 Jun 12. J Biol Chem. 2024. PMID: 38876305 Free PMC article.
Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge.
Karasmanis EP, Reimer JM, Kendrick AA, Nguyen KHV, Rodriguez JA, Truong JB, Lahiri I, Reck-Peterson SL, Leschziner AE. Karasmanis EP, et al. Nat Struct Mol Biol. 2023 Sep;30(9):1357-1364. doi: 10.1038/s41594-023-01069-6. Epub 2023 Aug 24. Nat Struct Mol Biol. 2023. PMID: 37620585 Free PMC article.
Structural basis for cytoplasmic dynein-1 regulation by Lis1.
Gillies JP, Reimer JM, Karasmanis EP, Lahiri I, Htet ZM, Leschziner AE, Reck-Peterson SL. Gillies JP, et al. Among authors: karasmanis ep. Elife. 2022 Jan 7;11:e71229. doi: 10.7554/eLife.71229. Elife. 2022. PMID: 34994688 Free PMC article.
12 results