Yu X - Search Results

1

Chemical Epigenetic Regulation of Adeno-Associated Virus Delivered Transgenes.

Umaña JD, Wasserman SR, Song L, Goel AA, Yu X, Jin J, Hathaway NA. Umaña JD, et al. Among authors: yu x. Hum Gene Ther. 2023 Sep;34(17-18):947-957. doi: 10.1089/hum.2023.005. Hum Gene Ther. 2023. PMID: 37624737 Free PMC article.

2

Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D₁ Receptor Agonists.

Martini ML, Liu J, Ray C, Yu X, Huang XP, Urs A, Urs N, McCorvy JD, Caron MG, Roth BL, Jin J. Martini ML, et al. Among authors: yu x. J Med Chem. 2019 Apr 11;62(7):3753-3772. doi: 10.1021/acs.jmedchem.9b00351. Epub 2019 Mar 27. J Med Chem. 2019. PMID: 30875219 Free PMC article.

3

Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68).

Yu X, Huang XP, Kenakin TP, Slocum ST, Chen X, Martini ML, Liu J, Jin J. Yu X, et al. J Med Chem. 2019 Aug 22;62(16):7557-7574. doi: 10.1021/acs.jmedchem.9b00869. Epub 2019 Aug 1. J Med Chem. 2019. PMID: 31298539 Free PMC article.

4

Designing Functionally Selective Noncatechol Dopamine D₁ Receptor Agonists with Potent In Vivo Antiparkinsonian Activity.

Martini ML, Ray C, Yu X, Liu J, Pogorelov VM, Wetsel WC, Huang XP, McCorvy JD, Caron MG, Jin J. Martini ML, et al. Among authors: yu x. ACS Chem Neurosci. 2019 Sep 18;10(9):4160-4182. doi: 10.1021/acschemneuro.9b00410. Epub 2019 Aug 20. ACS Chem Neurosci. 2019. PMID: 31387346 Free PMC article.

5

Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery.

Chiarella AM, Butler KV, Gryder BE, Lu D, Wang TA, Yu X, Pomella S, Khan J, Jin J, Hathaway NA. Chiarella AM, et al. Among authors: yu x. Nat Biotechnol. 2020 Jan;38(1):50-55. doi: 10.1038/s41587-019-0296-7. Epub 2019 Nov 11. Nat Biotechnol. 2020. PMID: 31712774 Free PMC article.

6

Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders.

Cheng M, Yu X, Lu K, Xie L, Wang L, Meng F, Han X, Chen X, Liu J, Xiong Y, Jin J. Cheng M, et al. Among authors: yu x. J Med Chem. 2020 Feb 13;63(3):1216-1232. doi: 10.1021/acs.jmedchem.9b01566. Epub 2020 Jan 14. J Med Chem. 2020. PMID: 31895569 Free PMC article.

7

Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders.

Shen Y, Gao G, Yu X, Kim H, Wang L, Xie L, Schwarz M, Chen X, Guccione E, Liu J, Bedford MT, Jin J. Shen Y, et al. Among authors: yu x. J Med Chem. 2020 Sep 10;63(17):9977-9989. doi: 10.1021/acs.jmedchem.0c01111. Epub 2020 Aug 21. J Med Chem. 2020. PMID: 32787082 Free PMC article.

8

ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism.

Li J, Galbo PM Jr, Gong W, Storey AJ, Tsai YH, Yu X, Ahn JH, Guo Y, Mackintosh SG, Edmondson RD, Byrum SD, Farrar JE, He S, Cai L, Jin J, Tackett AJ, Zheng D, Wang GG. Li J, et al. Among authors: yu x. Nat Commun. 2021 Feb 16;12(1):1045. doi: 10.1038/s41467-021-21357-3. Nat Commun. 2021. PMID: 33594072 Free PMC article.

9

Inhibition of EZH2 primes the cardiac gene activation via removal of epigenetic repression during human direct cardiac reprogramming.

Tang Y, Zhao L, Yu X, Zhang J, Qian L, Jin J, Lu R, Zhou Y. Tang Y, et al. Among authors: yu x. Stem Cell Res. 2021 May;53:102365. doi: 10.1016/j.scr.2021.102365. Epub 2021 Apr 27. Stem Cell Res. 2021. PMID: 34087994 Free PMC article.

10

AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B.

Xu J, Yu X, Martin TC, Bansal A, Cheung K, Lubin A, Stratikopoulos E, Cahuzac KM, Wang L, Xie L, Zhou R, Shen Y, Wu X, Yao S, Qiao R, Poulikakos PI, Chen X, Liu J, Jin J, Parsons R. Xu J, et al. Among authors: yu x. Cancer Discov. 2021 Dec 1;11(12):3064-3089. doi: 10.1158/2159-8290.CD-20-0815. Cancer Discov. 2021. PMID: 34301793 Free PMC article.

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