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21 results

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KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells.
Mahadevan KK, McAndrews KM, LeBleu VS, Yang S, Lyu H, Li B, Sockwell AM, Kirtley ML, Morse SJ, Moreno Diaz BA, Kim MP, Feng N, Lopez AM, Guerrero PA, Paradiso F, Sugimoto H, Arian KA, Ying H, Barekatain Y, Sthanam LK, Kelly PJ, Maitra A, Heffernan TP, Kalluri R. Mahadevan KK, et al. Cancer Cell. 2023 Sep 11;41(9):1606-1620.e8. doi: 10.1016/j.ccell.2023.07.002. Epub 2023 Aug 24. Cancer Cell. 2023. PMID: 37625401 Free PMC article.
Oncogenic Kras G12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8 + T cells dependent manner.
Mahadevan KK, McAndrews KM, LeBleu VS, Yang S, Lyu H, Li B, Sockwell AM, Kirtley ML, Morse SJ, Moreno Diaz BA, Kim MP, Feng N, Lopez AM, Guerrero PA, Sugimoto H, Arian KA, Ying H, Barekatain Y, Kelly PJ, Maitra A, Heffernan TP, Kalluri R. Mahadevan KK, et al. bioRxiv [Preprint]. 2023 Feb 18:2023.02.15.528757. doi: 10.1101/2023.02.15.528757. bioRxiv. 2023. PMID: 36824971 Free PMC article. Preprint.
Antigen-presenting type-I conventional dendritic cells facilitate curative checkpoint blockade immunotherapy in pancreatic cancer.
Mahadevan KK, Dyevoich AM, Chen Y, Li B, Sugimoto H, Sockwell AM, McAndrews KM, Wang H, Shalapour S, Watowich SS, Kalluri R. Mahadevan KK, et al. bioRxiv [Preprint]. 2023 Mar 6:2023.03.05.531191. doi: 10.1101/2023.03.05.531191. bioRxiv. 2023. Update in: Science. 2024 Jun 28;384(6703):eadh4567. doi: 10.1126/science.adh4567 PMID: 36945457 Free PMC article. Updated. Preprint.
Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells.
Mahadevan KK, LeBleu VS, Ramirez EV, Chen Y, Li B, Sockwell AM, Gagea M, Sugimoto H, Sthanam LK, Tampe D, Zeisberg M, Ying H, Jain AK, DePinho RA, Maitra A, McAndrews KM, Kalluri R. Mahadevan KK, et al. Dev Cell. 2023 Sep 11;58(17):1562-1577.e8. doi: 10.1016/j.devcel.2023.07.025. Epub 2023 Aug 24. Dev Cell. 2023. PMID: 37625403 Free PMC article.
Development of an engineered extracellular vesicles-based vaccine platform for combined delivery of mRNA and protein to induce functional immunity.
Luo X, McAndrews KM, Arian KA, Morse SJ, Boeker V, Kumbhar SV, Hu Y, Mahadevan KK, Church KA, Chitta S, Ryujin NT, Hensel J, Dai J, Dowlatshahi DP, Sugimoto H, Kirtley ML, LeBleu VS, Shalapour S, Simmons JH, Kalluri R. Luo X, et al. Among authors: mahadevan kk. J Control Release. 2024 Oct;374:550-562. doi: 10.1016/j.jconrel.2024.08.017. Epub 2024 Aug 30. J Control Release. 2024. PMID: 39146981
Uncloaking cell-impermeant gold nanorods via tumor microenvironmental cathepsin B facilitates cancer cell penetration and potent radiosensitization.
Raghuram S, Mackeyev Y, Symons J, Zahra Y, Gonzalez V, Mahadevan KK, Requejo KI, Liopo A, Derry P, Zubarev E, Sahin O, Byung-Kyu Kim J, Singh PK, Cho SH, Krishnan S. Raghuram S, et al. Among authors: mahadevan kk. Biomaterials. 2022 Dec;291:121887. doi: 10.1016/j.biomaterials.2022.121887. Epub 2022 Nov 2. Biomaterials. 2022. PMID: 36368139 Free PMC article.
21 results