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Introduction of a polar core into the de novo designed protein Top7.
Basanta B, Chan KK, Barth P, King T, Sosnick TR, Hinshaw JR, Liu G, Everett JK, Xiao R, Montelione GT, Baker D. Basanta B, et al. Among authors: baker d. Protein Sci. 2016 Jul;25(7):1299-307. doi: 10.1002/pro.2899. Epub 2016 Mar 7. Protein Sci. 2016. PMID: 26873166 Free PMC article.
Accurate de novo design of hyperstable constrained peptides.
Bhardwaj G, Mulligan VK, Bahl CD, Gilmore JM, Harvey PJ, Cheneval O, Buchko GW, Pulavarti SV, Kaas Q, Eletsky A, Huang PS, Johnsen WA, Greisen PJ, Rocklin GJ, Song Y, Linsky TW, Watkins A, Rettie SA, Xu X, Carter LP, Bonneau R, Olson JM, Coutsias E, Correnti CE, Szyperski T, Craik DJ, Baker D. Bhardwaj G, et al. Among authors: baker d. Nature. 2016 Oct 20;538(7625):329-335. doi: 10.1038/nature19791. Epub 2016 Sep 14. Nature. 2016. PMID: 27626386 Free PMC article.
Computational design of a homotrimeric metalloprotein with a trisbipyridyl core.
Mills JH, Sheffler W, Ener ME, Almhjell PJ, Oberdorfer G, Pereira JH, Parmeggiani F, Sankaran B, Zwart PH, Baker D. Mills JH, et al. Among authors: baker d. Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15012-15017. doi: 10.1073/pnas.1600188113. Epub 2016 Dec 8. Proc Natl Acad Sci U S A. 2016. PMID: 27940918 Free PMC article.
Principles for designing proteins with cavities formed by curved β sheets.
Marcos E, Basanta B, Chidyausiku TM, Tang Y, Oberdorfer G, Liu G, Swapna GV, Guan R, Silva DA, Dou J, Pereira JH, Xiao R, Sankaran B, Zwart PH, Montelione GT, Baker D. Marcos E, et al. Among authors: baker d. Science. 2017 Jan 13;355(6321):201-206. doi: 10.1126/science.aah7389. Science. 2017. PMID: 28082595 Free PMC article.
Computational design of self-assembling cyclic protein homo-oligomers.
Fallas JA, Ueda G, Sheffler W, Nguyen V, McNamara DE, Sankaran B, Pereira JH, Parmeggiani F, Brunette TJ, Cascio D, Yeates TR, Zwart P, Baker D. Fallas JA, et al. Among authors: baker d. Nat Chem. 2017 Apr;9(4):353-360. doi: 10.1038/nchem.2673. Epub 2016 Dec 5. Nat Chem. 2017. PMID: 28338692 Free PMC article.
Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site.
Strauch EM, Bernard SM, La D, Bohn AJ, Lee PS, Anderson CE, Nieusma T, Holstein CA, Garcia NK, Hooper KA, Ravichandran R, Nelson JW, Sheffler W, Bloom JD, Lee KK, Ward AB, Yager P, Fuller DH, Wilson IA, Baker D. Strauch EM, et al. Among authors: baker d. Nat Biotechnol. 2017 Jul;35(7):667-671. doi: 10.1038/nbt.3907. Epub 2017 Jun 12. Nat Biotechnol. 2017. PMID: 28604661 Free PMC article.
Cyclic oligomer design with de novo αβ-proteins.
Lin YR, Koga N, Vorobiev SM, Baker D. Lin YR, et al. Among authors: baker d. Protein Sci. 2017 Nov;26(11):2187-2194. doi: 10.1002/pro.3270. Protein Sci. 2017. PMID: 28801928 Free PMC article.
5,808 results