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Page 1
Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials.
Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Delucchi KL, Liu KD, Russell JA, Matthay MA, Walley KR, Ware LB, Calfee CS. Sinha P, et al. Among authors: leligdowicz a. Lancet Respir Med. 2023 Nov;11(11):965-974. doi: 10.1016/S2213-2600(23)00237-0. Epub 2023 Aug 23. Lancet Respir Med. 2023. PMID: 37633303 Free PMC article.
Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS.
Alipanah-Lechner N, Neyton L, Mick E, Willmore A, Leligdowicz A, Contrepois K, Jauregui A, Zhuo H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Matthay MA, Rogers AJ, Calfee CS. Alipanah-Lechner N, et al. Among authors: leligdowicz a. Am J Physiol Lung Cell Mol Physiol. 2023 Mar 1;324(3):L297-L306. doi: 10.1152/ajplung.00278.2022. Epub 2023 Jan 17. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 36648136 Free PMC article.
Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis.
Rosenberger CM, Wick KD, Zhuo H, Wu N, Chen Y, Kapadia SB, Guimaraes A, Chang D, Choy DF, Chen H, Peck M, Sullivan KM, Ke S, Jauregui A, Leligdowicz A, Sinha P, Gomez AD, Kangelaris KN, Delucchi K, Liu KD, Calfee CS, Matthay MA, Hendrickson CM. Rosenberger CM, et al. Among authors: leligdowicz a. Crit Care. 2023 Jun 13;27(1):234. doi: 10.1186/s13054-023-04525-3. Crit Care. 2023. PMID: 37312169 Free PMC article.
A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling.
Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, Krummel MF, Erle DJ, Kangelaris K, Sarma A, Lyon Z, Calfee CS, Woodruff PG, Ghale R, Mick E, Byrne A, Zha BS, Langelier C, Hendrickson CM, van der Wijst MGP, Hartoularos GC, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Ye CJ; UCSF COMET Consortium; Ramalingam T, McBride JM, Cai F, Teterina A, Bao M, Tsai L, Rosas IO, Regev A, Kapadia SB, Bauer RN, Rosenberger CM. Hackney JA, et al. iScience. 2023 Sep 1;26(10):107813. doi: 10.1016/j.isci.2023.107813. eCollection 2023 Oct 20. iScience. 2023. PMID: 37810211 Free PMC article.
Annexin A5 in Patients With Severe COVID-19 Disease: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Feasibility Trial.
Martin CM, Slessarev M, Campbell E, Basmaji J, Ball I, Fraser DD, Leligdowicz A, Mele T, Priestap F, Tschirhart BJ, Bentall T, Lu X, Feng Q. Martin CM, et al. Among authors: leligdowicz a. Crit Care Explor. 2023 Oct 5;5(10):e0986. doi: 10.1097/CCE.0000000000000986. eCollection 2023 Oct. Crit Care Explor. 2023. PMID: 37811130 Free PMC article.
Gaps and opportunities in sepsis translational research.
Marshall JC, Leligdowicz A. Marshall JC, et al. Among authors: leligdowicz a. EBioMedicine. 2022 Dec;86:104387. doi: 10.1016/j.ebiom.2022.104387. Epub 2022 Dec 2. EBioMedicine. 2022. PMID: 36470831 Free PMC article. Review.
100 results