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Page 1
Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection.
Yang F, Beltran-Lobo P, Sung K, Goldrick C, Croft CL, Nishimura A, Hedges E, Mahiddine F, Troakes C, Golde TE, Perez-Nievas BG, Hanger DP, Noble W, Jimenez-Sanchez M. Yang F, et al. Among authors: beltran lobo p. Sci Adv. 2024 Mar 22;10(12):eadk9884. doi: 10.1126/sciadv.adk9884. Epub 2024 Mar 20. Sci Adv. 2024. PMID: 38507480 Free PMC article.
P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes.
Beltran-Lobo P, Hughes MM, Troakes C, Croft CL, Rupawala H, Jutzi D, Ruepp MD, Jimenez-Sanchez M, Perkinton MS, Kassiou M, Golde TE, Hanger DP, Verkhratsky A, Perez-Nievas BG, Noble W. Beltran-Lobo P, et al. Brain Behav Immun. 2023 Nov;114:414-429. doi: 10.1016/j.bbi.2023.09.011. Epub 2023 Sep 15. Brain Behav Immun. 2023. PMID: 37716378 Free PMC article.
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.
Nutma E, Fancy N, Weinert M, Tsartsalis S, Marzin MC, Muirhead RCJ, Falk I, Breur M, de Bruin J, Hollaus D, Pieterman R, Anink J, Story D, Chandran S, Tang J, Trolese MC, Saito T, Saido TC, Wiltshire KH, Beltran-Lobo P, Phillips A, Antel J, Healy L, Dorion MF, Galloway DA, Benoit RY, Amossé Q, Ceyzériat K, Badina AM, Kövari E, Bendotti C, Aronica E, Radulescu CI, Wong JH, Barron AM, Smith AM, Barnes SJ, Hampton DW, van der Valk P, Jacobson S, Howell OW, Baker D, Kipp M, Kaddatz H, Tournier BB, Millet P, Matthews PM, Moore CS, Amor S, Owen DR. Nutma E, et al. Among authors: beltran lobo p. Nat Commun. 2023 Aug 28;14(1):5247. doi: 10.1038/s41467-023-40937-z. Nat Commun. 2023. PMID: 37640701 Free PMC article.
Astrocytic C-X-C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity.
Perez-Nievas BG, Johnson L, Beltran-Lobo P, Hughes MM, Gammallieri L, Tarsitano F, Myszczynska MA, Vazquez-Villasenor I, Jimenez-Sanchez M, Troakes C, Wharton SB, Ferraiuolo L, Noble W. Perez-Nievas BG, et al. Among authors: beltran lobo p. J Neuroinflammation. 2021 Dec 28;18(1):306. doi: 10.1186/s12974-021-02371-0. J Neuroinflammation. 2021. PMID: 34963475 Free PMC article.
Astrocytes in Tauopathies.
Reid MJ, Beltran-Lobo P, Johnson L, Perez-Nievas BG, Noble W. Reid MJ, et al. Among authors: beltran lobo p. Front Neurol. 2020 Sep 24;11:572850. doi: 10.3389/fneur.2020.572850. eCollection 2020. Front Neurol. 2020. PMID: 33071951 Free PMC article. Review.