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Venetoclax, alone and in combination with the BH3 mimetic S63845, depletes HIV-1 latently infected cells and delays rebound in humanized mice.
Arandjelovic P, Kim Y, Cooney JP, Preston SP, Doerflinger M, McMahon JH, Garner SE, Zerbato JM, Roche M, Tumpach C, Ong J, Sheerin D, Smyth GK, Anderson JL, Allison CC, Lewin SR, Pellegrini M. Arandjelovic P, et al. Among authors: zerbato jm. Cell Rep Med. 2023 Sep 19;4(9):101178. doi: 10.1016/j.xcrm.2023.101178. Epub 2023 Aug 30. Cell Rep Med. 2023. PMID: 37652018 Free PMC article.
A cure for HIV: how would we know?
Zerbato JM, Lewin SR. Zerbato JM, et al. Lancet HIV. 2020 May;7(5):e304-e306. doi: 10.1016/S2352-3018(20)30075-8. Epub 2020 Mar 10. Lancet HIV. 2020. PMID: 32169159 Free article. No abstract available.
Memory CD4+ T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency.
Rasmussen TA, Zerbato JM, Rhodes A, Tumpach C, Dantanarayana A, McMahon JH, Lau JSY, Chang JJ, Gubser C, Brown W, Hoh R, Krone M, Pascoe R, Chiu CY, Bramhall M, Lee HJ, Haque A, Fromentin R, Chomont N, Milush J, Van der Sluis RM, Palmer S, Deeks SG, Cameron PU, Evans V, Lewin SR. Rasmussen TA, et al. Among authors: zerbato jm. Cell Rep Med. 2022 Oct 18;3(10):100766. doi: 10.1016/j.xcrm.2022.100766. Epub 2022 Oct 4. Cell Rep Med. 2022. PMID: 36198308 Free PMC article.
Combination Immune Checkpoint Blockade to Reverse HIV Latency.
Van der Sluis RM, Kumar NA, Pascoe RD, Zerbato JM, Evans VA, Dantanarayana AI, Anderson JL, Sékaly RP, Fromentin R, Chomont N, Cameron PU, Lewin SR. Van der Sluis RM, et al. Among authors: zerbato jm. J Immunol. 2020 Mar 1;204(5):1242-1254. doi: 10.4049/jimmunol.1901191. Epub 2020 Jan 27. J Immunol. 2020. PMID: 31988180 Free PMC article.
A clinical trial of non-invasive imaging with an anti-HIV antibody labelled with copper-64 in people living with HIV and uninfected controls.
McMahon JH, Zerbato JM, Lau JSY, Lange JL, Roche M, Tumpach C, Dantanarayana A, Rhodes A, Chang J, Rasmussen TA, Mackenzie CA, Alt K, Hagenauer M, Roney J, O'Bryan J, Carey A, McIntyre R, Beech P, O'Keefe GJ, Wichmann CW, Scott FE, Guo N, Lee ST, Liu Z, Caskey M, Nussenzweig MC, Donnelly PS, Egan G, Hagemeyer CE, Scott AM, Lewin SR. McMahon JH, et al. Among authors: zerbato jm. EBioMedicine. 2021 Mar;65:103252. doi: 10.1016/j.ebiom.2021.103252. Epub 2021 Feb 25. EBioMedicine. 2021. PMID: 33640794 Free PMC article. Clinical Trial.
Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency.
Zerbato JM, Khoury G, Zhao W, Gartner MJ, Pascoe RD, Rhodes A, Dantanarayana A, Gooey M, Anderson J, Bacchetti P, Deeks SG, McMahon J, Roche M, Rasmussen TA, Purcell DF, Lewin SR. Zerbato JM, et al. EBioMedicine. 2021 Mar;65:103241. doi: 10.1016/j.ebiom.2021.103241. Epub 2021 Feb 26. EBioMedicine. 2021. PMID: 33647768 Free PMC article.
HIV DNA persists in hepatocytes in people with HIV-hepatitis B co-infection on antiretroviral therapy.
Zerbato JM, Avihingsanon A, Singh KP, Zhao W, Deleage C, Rosen E, Cottrell ML, Rhodes A, Dantanarayana A, Tumpach C, Tennakoon S, Crane M, Price DJ, Braat S, Mason H, Roche M, Kashuba ADM, Revill PA, Audsley J, Lewin SR. Zerbato JM, et al. EBioMedicine. 2023 Jan;87:104391. doi: 10.1016/j.ebiom.2022.104391. Epub 2022 Dec 8. EBioMedicine. 2023. PMID: 36502576 Free PMC article.
Persistence of envelopes in different CD4+ T-cell subsets in antiretroviral therapy-suppressed people with HIV.
Gartner MJ, Tumpach C, Dantanarayana A, Stern J, Zerbato JM, Chang JJ, Angelovich TA, Anderson JL, Symons J, Deeks SG, Flynn JK, Lewin SR, Churchill MJ, Gorry PR, Roche M. Gartner MJ, et al. Among authors: zerbato jm. AIDS. 2023 Feb 1;37(2):247-257. doi: 10.1097/QAD.0000000000003424. Epub 2022 Nov 18. AIDS. 2023. PMID: 36541637 Free PMC article.
26 results