Wen G - Search Results

1

Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1-BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy.

Yue X, Liu T, Wang X, Wu W, Wen G, Yi Y, Wu J, Wang Z, Zhan W, Wu R, Meng Y, Cao Z, Le L, Qiu W, Zhang X, Li Z, Chen Y, Wan G, Bu X, Peng Z, Liu RY. Yue X, et al. Among authors: wen g. Acta Pharm Sin B. 2023 Aug;13(8):3382-3399. doi: 10.1016/j.apsb.2023.05.017. Epub 2023 May 19. Acta Pharm Sin B. 2023. PMID: 37655321 Free PMC article.

2

Synthesis, cytotoxicity of new 4-arylidene curcumin analogues and their multi-functions in inhibition of both NF-κB and Akt signalling.

Zuo Y, Huang J, Zhou B, Wang S, Shao W, Zhu C, Lin L, Wen G, Wang H, Du J, Bu X. Zuo Y, et al. Among authors: wen g. Eur J Med Chem. 2012 Sep;55:346-57. doi: 10.1016/j.ejmech.2012.07.039. Epub 2012 Jul 31. Eur J Med Chem. 2012. PMID: 22889562

3

Synthesis and identification of new flavonoids targeting liver X receptor β involved pathway as potential facilitators of Aβ clearance with reduced lipid accumulation.

Hu Y, Yang Y, Yu Y, Wen G, Shang N, Zhuang W, Lu D, Zhou B, Liang B, Yue X, Li F, Du J, Bu X. Hu Y, et al. Among authors: wen g. J Med Chem. 2013 Aug 8;56(15):6033-53. doi: 10.1021/jm301913k. Epub 2013 Jul 26. J Med Chem. 2013. PMID: 23844653

4

A furanyl acryl conjugated coumarin as an efficient inhibitor and a highly selective off-on fluorescent probe for covalent labelling of thioredoxin reductase.

Huang L, Chen Y, Liang B, Xing B, Wen G, Wang S, Yue X, Zhu C, Du J, Bu X. Huang L, et al. Among authors: wen g. Chem Commun (Camb). 2014 Jul 7;50(53):6987-90. doi: 10.1039/c4cc02119c. Chem Commun (Camb). 2014. PMID: 24844612

5

Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence.

Zhu C, Zuo Y, Wang R, Liang B, Yue X, Wen G, Shang N, Huang L, Chen Y, Du J, Bu X. Zhu C, et al. Among authors: wen g. J Med Chem. 2014 Aug 14;57(15):6364-82. doi: 10.1021/jm500024v. Epub 2014 Jul 25. J Med Chem. 2014. PMID: 25061803

6

Distinct tubulin dynamics in cancer cells explored using a highly tubulin-specific fluorescent probe.

Zhu C, Zuo Y, Liang B, Yue H, Yue X, Wen G, Wang R, Quan J, Du J, Bu X. Zhu C, et al. Among authors: wen g. Chem Commun (Camb). 2015 Sep 7;51(69):13400-3. doi: 10.1039/c5cc04927j. Epub 2015 Jul 27. Chem Commun (Camb). 2015. PMID: 26214302

7

Mitochondria-Targeted Approach: Remarkably Enhanced Cellular Bioactivities of TPP2a as Selective Inhibitor and Probe toward TrxR.

Liang B, Shao W, Zhu C, Wen G, Yue X, Wang R, Quan J, Du J, Bu X. Liang B, et al. Among authors: wen g. ACS Chem Biol. 2016 Feb 19;11(2):425-34. doi: 10.1021/acschembio.5b00708. Epub 2015 Dec 14. ACS Chem Biol. 2016. PMID: 26653078

8

MC37, a new mono-carbonyl curcumin analog, induces G2/M cell cycle arrest and mitochondria-mediated apoptosis in human colorectal cancer cells.

Liang B, Liu Z, Cao Y, Zhu C, Zuo Y, Huang L, Wen G, Shang N, Chen Y, Yue X, Du J, Li B, Zhou B, Bu X. Liang B, et al. Among authors: wen g. Eur J Pharmacol. 2017 Feb 5;796:139-148. doi: 10.1016/j.ejphar.2016.12.030. Epub 2016 Dec 23. Eur J Pharmacol. 2017. PMID: 28024945

9

Stabilizing the monomeric amyloid-β peptide by tyrocidine A prevents and reverses amyloidogenesis without the accumulation of oligomers.

Wen G, Qin W, Chen D, Wang Y, Yue X, Liu Z, Cao Y, Du J, Zhou B, Bu X. Wen G, et al. Chem Commun (Camb). 2017 Mar 30;53(27):3886-3889. doi: 10.1039/c7cc00506g. Chem Commun (Camb). 2017. PMID: 28317984

10

Identification of 4-arylidene curcumin analogues as novel proteasome inhibitors for potential anticancer agents targeting 19S regulatory particle associated deubiquitinase.

Yue X, Zuo Y, Ke H, Luo J, Lou L, Qin W, Wang Y, Liu Z, Chen D, Sun H, Zheng W, Zhu C, Wang R, Wen G, Du J, Zhou B, Bu X. Yue X, et al. Among authors: wen g. Biochem Pharmacol. 2017 Aug 1;137:29-50. doi: 10.1016/j.bcp.2017.04.032. Epub 2017 May 3. Biochem Pharmacol. 2017. PMID: 28476333

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