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P450-mediated dehydrotyrosine formation during WS9326 biosynthesis proceeds via dehydrogenation of a specific acylated dipeptide substrate.
Zhang S, Zhang L, Greule A, Tailhades J, Marschall E, Prasongpholchai P, Leng DJ, Zhang J, Zhu J, Kaczmarski JA, Schittenhelm RB, Einsle O, Jackson CJ, Alberti F, Bechthold A, Zhang Y, Tosin M, Si T, Cryle MJ. Zhang S, et al. Among authors: schittenhelm rb. Acta Pharm Sin B. 2023 Aug;13(8):3561-3574. doi: 10.1016/j.apsb.2023.03.021. Epub 2023 Mar 29. Acta Pharm Sin B. 2023. PMID: 37655329 Free PMC article.
SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control.
Montgomery MK, Bayliss J, Devereux C, Bezawork-Geleta A, Roberts D, Huang C, Schittenhelm RB, Ryan A, Townley SL, Selth LA, Biden TJ, Steinberg GR, Samocha-Bonet D, Meex RCR, Watt MJ. Montgomery MK, et al. Among authors: schittenhelm rb. Sci Transl Med. 2020 Sep 2;12(559):eaaz8048. doi: 10.1126/scitranslmed.aaz8048. Sci Transl Med. 2020. PMID: 32878981
Biochemical membrane lipidomics during Drosophila development.
Guan XL, Cestra G, Shui G, Kuhrs A, Schittenhelm RB, Hafen E, van der Goot FG, Robinett CC, Gatti M, Gonzalez-Gaitan M, Wenk MR. Guan XL, et al. Among authors: schittenhelm rb. Dev Cell. 2013 Jan 14;24(1):98-111. doi: 10.1016/j.devcel.2012.11.012. Epub 2012 Dec 20. Dev Cell. 2013. PMID: 23260625 Free article.
Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome.
Glatter T, Schittenhelm RB, Rinner O, Roguska K, Wepf A, Jünger MA, Köhler K, Jevtov I, Choi H, Schmidt A, Nesvizhskii AI, Stocker H, Hafen E, Aebersold R, Gstaiger M. Glatter T, et al. Among authors: schittenhelm rb. Mol Syst Biol. 2011 Nov 8;7:547. doi: 10.1038/msb.2011.79. Mol Syst Biol. 2011. PMID: 22068330 Free PMC article.
141 results