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P450-mediated dehydrotyrosine formation during WS9326 biosynthesis proceeds via dehydrogenation of a specific acylated dipeptide substrate.
Zhang S, Zhang L, Greule A, Tailhades J, Marschall E, Prasongpholchai P, Leng DJ, Zhang J, Zhu J, Kaczmarski JA, Schittenhelm RB, Einsle O, Jackson CJ, Alberti F, Bechthold A, Zhang Y, Tosin M, Si T, Cryle MJ. Zhang S, et al. Among authors: zhang l, zhang j, zhang y. Acta Pharm Sin B. 2023 Aug;13(8):3561-3574. doi: 10.1016/j.apsb.2023.03.021. Epub 2023 Mar 29. Acta Pharm Sin B. 2023. PMID: 37655329 Free PMC article.
Structural biology of proteins involved in nitrogen cycling.
Lycus P, Einsle O, Zhang L. Lycus P, et al. Among authors: zhang l. Curr Opin Chem Biol. 2023 Jun;74:102278. doi: 10.1016/j.cbpa.2023.102278. Epub 2023 Mar 6. Curr Opin Chem Biol. 2023. PMID: 36889028 Review.
Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD+-Dependent Lysine Deacylase Sirtuin 2.
Colcerasa A, Friedrich F, Melesina J, Moser P, Vogelmann A, Tzortzoglou P, Neuwirt E, Sum M, Robaa D, Zhang L, Ramos-Morales E, Romier C, Einsle O, Metzger E, Schüle R, Groß O, Sippl W, Jung M. Colcerasa A, et al. Among authors: zhang l. J Med Chem. 2024 Jun 27;67(12):10076-10095. doi: 10.1021/acs.jmedchem.4c00229. Epub 2024 Jun 7. J Med Chem. 2024. PMID: 38847803
Prourokinase vs Standard Care for Patients With Mild Ischemic Stroke: The PUMICE Randomized Clinical Trial.
Xiong Y, Meng X, Jin A, Campbell BCV, Xu A, Dong Q, Xu Y, Pan Y, Jiang Y, Niu S, Li Z, Zhuang X, Guo N, Yuan Z, Kong Z, Zong L, Duan C, Cao Z, Wang L, Hao M, Wu S, Feng X, Li H, Wu N, Li Z, Zhao X, Wang Y; PUMICE Investigators. Xiong Y, et al. JAMA Neurol. 2025 Jan 21. doi: 10.1001/jamaneurol.2024.4688. Online ahead of print. JAMA Neurol. 2025. PMID: 39836393
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