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Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice.
Seedorf K, Weber C, Vinson C, Berger S, Vuillard LM, Kiss A, Creusot S, Broux O, Geant A, Ilic C, Lemaitre K, Richard J, Hammoutene A, Mahieux J, Martiny V, Durand D, Melchiore F, Nyerges M, Paradis V, Provost N, Duvivier V, Delerive P. Seedorf K, et al. Among authors: delerive p. JHEP Rep. 2022 Dec 16;5(4):100651. doi: 10.1016/j.jhepr.2022.100651. eCollection 2023 Apr. JHEP Rep. 2022. PMID: 36866391 Free PMC article.
Covalent Inhibitors of KEAP1 with Exquisite Selectivity.
Fejes I, Markacz P, Tatai J, Rudas M, Dunkel P, Gyuris M, Nyerges M, Provost N, Duvivier V, Delerive P, Martiny V, Bristiel A, Vidal B, Richardson W, Rothweiler EM, Tranberg-Jensen J, Manning CE, Sweeney MN, Chalk R, Huber KVM, Bullock AN, Herner A, Seedorf K, Vinson C, Weber C, Kotschy A. Fejes I, et al. Among authors: delerive p. J Med Chem. 2024 Dec 12;67(23):21208-21222. doi: 10.1021/acs.jmedchem.4c02019. Epub 2024 Nov 21. J Med Chem. 2024. PMID: 39572012 Free PMC article.
Prospective head-to-head comparison of non-invasive scores for diagnosis of fibrotic MASH in patients with type 2 diabetes.
Castera L, Garteiser P, Laouenan C, Vidal-Trécan T, Vallet-Pichard A, Manchon P, Paradis V, Czernichow S, Roulot D, Larger E, Pol S, Bedossa P, Correas JM, Valla D, Gautier JF, Van Beers BE; QUID NASH investigators. Castera L, et al. J Hepatol. 2024 Aug;81(2):195-206. doi: 10.1016/j.jhep.2024.03.023. Epub 2024 Mar 27. J Hepatol. 2024. PMID: 38548067
Characterization and Pharmacological Validation of a Preclinical Model of NASH in Göttingen Minipigs.
Duvivier V, Creusot S, Broux O, Helbert A, Lesage L, Moreau K, Lesueur N, Gerard L, Lemaitre K, Provost N, Hubert EL, Baltauss T, Brzustowski A, De Preville N, Geronimi J, Adoux L, Letourneur F, Hammoutene A, Valla D, Paradis V, Delerive P. Duvivier V, et al. Among authors: delerive p. J Clin Exp Hepatol. 2022 Mar-Apr;12(2):293-305. doi: 10.1016/j.jceh.2021.09.001. Epub 2021 Sep 8. J Clin Exp Hepatol. 2022. PMID: 35535064 Free PMC article.
Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms.
Riddy DM, Kammoun HL, Murphy AJ, Bosnyak-Gladovic S, De la Fuente Gonzalez R, Merlin J, Ziemann M, Fabb S, Pierce TL, Diepenhorst N, Rueda P, El-Osta A, Gautier JF, Venteclef N, Charman WN, Christopoulos A, Sexton PM, Summers RJ, Febbraio MA, Delerive P, Langmead CJ. Riddy DM, et al. Among authors: delerive p. BMJ Open Diabetes Res Care. 2021 Nov;9(2):e002285. doi: 10.1136/bmjdrc-2021-002285. BMJ Open Diabetes Res Care. 2021. PMID: 34782333 Free PMC article.
Deficiency of Procollagen C-Proteinase Enhancer 1 in Mice has No Major Impact on Cardiac Collagen and Function Under Basal Conditions.
Sansilvestri-Morel P, Harouki-Crochemore N, Bertin F, Bertheux H, Vermeil de Conchard G, Diguet N, Desfosses E, Lecomte M, Gonzalez A, Diez J, Tupinon-Mathieu I, Delerive P. Sansilvestri-Morel P, et al. Among authors: delerive p. J Cardiovasc Pharmacol. 2021 Nov 1;78(5):e703-e713. doi: 10.1097/FJC.0000000000001122. J Cardiovasc Pharmacol. 2021. PMID: 34369899
Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes.
Wigger L, Barovic M, Brunner AD, Marzetta F, Schöniger E, Mehl F, Kipke N, Friedland D, Burdet F, Kessler C, Lesche M, Thorens B, Bonifacio E, Legido-Quigley C, Barbier Saint Hilaire P, Delerive P, Dahl A, Klose C, Gerl MJ, Simons K, Aust D, Weitz J, Distler M, Schulte AM, Mann M, Ibberson M, Solimena M. Wigger L, et al. Among authors: delerive p. Nat Metab. 2021 Jul;3(7):1017-1031. doi: 10.1038/s42255-021-00420-9. Epub 2021 Jun 28. Nat Metab. 2021. PMID: 34183850
49 results