Arafa RK - Search Results

1

Computer-assisted drug discovery of potential natural inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase through a multi-phase in silico approach.

Elkaeed EB, Alsfouk BA, Ibrahim TH, Arafa RK, Elkady H, Ibrahim IM, Eissa IH, Metwaly AM. Elkaeed EB, et al. Among authors: arafa rk. Antivir Ther. 2023 Oct;28(5):13596535231199838. doi: 10.1177/13596535231199838. Antivir Ther. 2023. PMID: 37669909 Free article.

2

Molecular determinants for DNA minor groove recognition: design of a bis-guanidinium derivative of ethidium that is highly selective for AT-rich DNA sequences.

Bailly C, Arafa RK, Tanious FA, Laine W, Tardy C, Lansiaux A, Colson P, Boykin DW, Wilson WD. Bailly C, et al. Among authors: arafa rk. Biochemistry. 2005 Feb 15;44(6):1941-52. doi: 10.1021/bi047983n. Biochemistry. 2005. PMID: 15697219

3

Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex.

Munde M, Lee M, Neidle S, Arafa R, Boykin DW, Liu Y, Bailly C, Wilson WD. Munde M, et al. J Am Chem Soc. 2007 May 2;129(17):5688-98. doi: 10.1021/ja069003n. Epub 2007 Apr 11. J Am Chem Soc. 2007. PMID: 17425312 Free PMC article.

4

In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi.

Gillingwater K, Kumar A, Ismail MA, Arafa RK, Stephens CE, Boykin DW, Tidwell RR, Brun R. Gillingwater K, et al. Among authors: arafa rk. Vet Parasitol. 2010 May 11;169(3-4):264-72. doi: 10.1016/j.vetpar.2010.01.019. Epub 2010 Jan 25. Vet Parasitol. 2010. PMID: 20149544

5

Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.

Patrick DA, Ismail MA, Arafa RK, Wenzler T, Zhu X, Pandharkar T, Jones SK, Werbovetz KA, Brun R, Boykin DW, Tidwell RR. Patrick DA, et al. Among authors: arafa rk. J Med Chem. 2013 Jul 11;56(13):5473-94. doi: 10.1021/jm400508e. Epub 2013 Jun 24. J Med Chem. 2013. PMID: 23795673

6

Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.

Hu L, Arafa RK, Ismail MA, Patel A, Munde M, Wilson WD, Wenzler T, Brun R, Boykin DW. Hu L, et al. Among authors: arafa rk. Bioorg Med Chem. 2009 Sep 15;17(18):6651-8. doi: 10.1016/j.bmc.2009.07.080. Epub 2009 Aug 7. Bioorg Med Chem. 2009. PMID: 19699098 Free PMC article.

7

Trypanocidal activity and selectivity in vitro of aromatic amidine compounds upon bloodstream and intracellular forms of Trypanosoma cruzi.

De Souza EM, da Silva PB, Nefertiti AS, Ismail MA, Arafa RK, Tao B, Nixon-Smith CK, Boykin DW, Soeiro MN. De Souza EM, et al. Among authors: arafa rk. Exp Parasitol. 2011 Feb;127(2):429-35. doi: 10.1016/j.exppara.2010.10.010. Epub 2010 Nov 11. Exp Parasitol. 2011. PMID: 20971106 Free article.

8

Induced topological changes in DNA complexes: influence of DNA sequences and small molecule structures.

Hunt RA, Munde M, Kumar A, Ismail MA, Farahat AA, Arafa RK, Say M, Batista-Parra A, Tevis D, Boykin DW, Wilson WD. Hunt RA, et al. Among authors: arafa rk. Nucleic Acids Res. 2011 May;39(10):4265-74. doi: 10.1093/nar/gkq1362. Epub 2011 Jan 25. Nucleic Acids Res. 2011. PMID: 21266485 Free PMC article.

9

Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif.

Munde M, Ismail MA, Arafa R, Peixoto P, Collar CJ, Liu Y, Hu L, David-Cordonnier MH, Lansiaux A, Bailly C, Boykin DW, Wilson WD. Munde M, et al. J Am Chem Soc. 2007 Nov 7;129(44):13732-43. doi: 10.1021/ja074560a. Epub 2007 Oct 13. J Am Chem Soc. 2007. PMID: 17935330 Free PMC article.

10

Cytotoxic activity of some novel sulfonamide derivatives.

Ghorab MM, Alsaid MS, Abdullah-al-Dhfyan, Arafa RK. Ghorab MM, et al. Among authors: arafa rk. Acta Pol Pharm. 2015 Jan-Feb;72(1):79-87. Acta Pol Pharm. 2015. PMID: 25850203 Free article.

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