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Large-scale prediction and testing of drug activity on side-effect targets.
Lounkine E, Keiser MJ, Whitebread S, Mikhailov D, Hamon J, Jenkins JL, Lavan P, Weber E, Doak AK, Côté S, Shoichet BK, Urban L. Lounkine E, et al. Among authors: keiser mj. Nature. 2012 Jun 10;486(7403):361-7. doi: 10.1038/nature11159. Nature. 2012. PMID: 22722194 Free PMC article.
Mild chronic perturbation of inhibition severely alters hippocampal function.
Sun MY, Ziolkowski L, Lambert P, Shu HJ, Keiser M, Rensing N, Warikoo N, Martinek M, Platnick C, Benz A, Bracamontes J, Akk G, Steinbach JH, Zorumski CF, Wong M, Mennerick S. Sun MY, et al. Sci Rep. 2019 Nov 11;9(1):16431. doi: 10.1038/s41598-019-52851-w. Sci Rep. 2019. PMID: 31712706 Free PMC article.
Systems pharmacology augments drug safety surveillance.
Lorberbaum T, Nasir M, Keiser MJ, Vilar S, Hripcsak G, Tatonetti NP. Lorberbaum T, et al. Among authors: keiser mj. Clin Pharmacol Ther. 2015 Feb;97(2):151-8. doi: 10.1002/cpt.2. Epub 2014 Dec 20. Clin Pharmacol Ther. 2015. PMID: 25670520 Free PMC article.
The presynaptic component of the serotonergic system is required for clozapine's efficacy.
Yadav PN, Abbas AI, Farrell MS, Setola V, Sciaky N, Huang XP, Kroeze WK, Crawford LK, Piel DA, Keiser MJ, Irwin JJ, Shoichet BK, Deneris ES, Gingrich J, Beck SG, Roth BL. Yadav PN, et al. Among authors: keiser mj. Neuropsychopharmacology. 2011 Feb;36(3):638-51. doi: 10.1038/npp.2010.195. Epub 2010 Nov 3. Neuropsychopharmacology. 2011. PMID: 21048700 Free PMC article.
Learning fast and fine-grained detection of amyloid neuropathologies from coarse-grained expert labels.
Wong DR, Magaki SD, Vinters HV, Yong WH, Monuki ES, Williams CK, Martini AC, DeCarli C, Khacherian C, Graff JP, Dugger BN, Keiser MJ. Wong DR, et al. Among authors: keiser mj. bioRxiv [Preprint]. 2023 Jan 17:2023.01.13.524019. doi: 10.1101/2023.01.13.524019. bioRxiv. 2023. Update in: Commun Biol. 2023 Jun 24;6(1):668. doi: 10.1038/s42003-023-05031-6 PMID: 36711704 Free PMC article. Updated. Preprint.
52 results