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Lhs1 dependent ERAD is determined by transmembrane domain context.
Sukhoplyasova M, Keith AM, Perrault EM, Vorndran HE, Jordahl AS, Yates ME, Pastor A, Li Z, Freaney ML, Deshpande RA, Adams DB, Guerriero CJ, Shi S, Kleyman TR, Kashlan OB, Brodsky JL, Buck TM. Sukhoplyasova M, et al. Among authors: brodsky jl. Biochem J. 2023 Sep 27;480(18):1459-1473. doi: 10.1042/BCJ20230075. Biochem J. 2023. PMID: 37702403 Free PMC article.
Characterization of hyperactive mutations in the renal potassium channel ROMK uncovers unique effects on channel biogenesis and ion conductance.
Nguyen NH, Sheng S, Banerjee A, Guerriero CJ, Chen J, Wang X, Mackie TD, Welling PA, Kleyman TR, Bahar I, Carlson AE, Brodsky JL. Nguyen NH, et al. Among authors: brodsky jl. Mol Biol Cell. 2024 Sep 1;35(9):ar119. doi: 10.1091/mbc.E23-12-0494. Epub 2024 Jul 18. Mol Biol Cell. 2024. PMID: 39024255 Free PMC article.
FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver.
Wang H, Nikain C, Fortounas KI, Amengual J, Tufanli O, La Forest M, Yu Y, Wang MC, Watts R, Lehner R, Qiu Y, Cai M, Kurland IJ, Goldberg IJ, Rajan S, Hussain MM, Brodsky JL, Fisher EA. Wang H, et al. Among authors: brodsky jl. Mol Metab. 2024 Dec;90:102048. doi: 10.1016/j.molmet.2024.102048. Epub 2024 Oct 18. Mol Metab. 2024. PMID: 39426520 Free PMC article.
Assays to measure small molecule Hsp70 agonist activity in vitro and in vivo.
Shapiro O, Woods C, Gleixner AM, Sannino S, Ngo M, McDaniels MD, Wipf P, Hukriede NA, Donnelly CJ, Brodsky JL. Shapiro O, et al. Among authors: brodsky jl. Anal Biochem. 2025 Feb;697:115712. doi: 10.1016/j.ab.2024.115712. Epub 2024 Nov 9. Anal Biochem. 2025. PMID: 39522672 Free article.
Optimization of the fluorogen-activating protein tag for quantitative protein trafficking and colocalization studies in S. cerevisiae.
Oppenheimer KG, Hager NA, McAtee CK, Filiztekin E, Shang C, Warnick JA, Bruchez MP, Brodsky JL, Prosser DC, Kwiatkowski AV, O'Donnell AF. Oppenheimer KG, et al. Among authors: brodsky jl. Mol Biol Cell. 2024 Jul 1;35(7):mr5. doi: 10.1091/mbc.E24-04-0174. Epub 2024 May 29. Mol Biol Cell. 2024. PMID: 38809589 Free PMC article.
290 results