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Excess dietary sodium restores electrolyte and water homeostasis caused by loss of the endoplasmic reticulum molecular chaperone, GRP170, in the mouse nephron.
Porter AW, Vorndran HE, Marciszyn A, Mutchler SM, Subramanya AR, Kleyman TR, Hendershot LM, Brodsky JL, Buck TM. Porter AW, et al. Among authors: vorndran he. Am J Physiol Renal Physiol. 2025 Feb 1;328(2):F173-F189. doi: 10.1152/ajprenal.00192.2024. Epub 2024 Nov 18. Am J Physiol Renal Physiol. 2025. PMID: 39556479
Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum function.
Mann MJ, Melendez-Suchi C, Vorndran HE, Sukhoplyasova M, Flory AR, Irvine MC, Iyer AR, Guerriero CJ, Brodsky JL, Hendershot LM, Buck TM. Mann MJ, et al. Among authors: vorndran he. Mol Biol Cell. 2024 Apr 1;35(4):ar59. doi: 10.1091/mbc.E24-01-0012. Epub 2024 Mar 6. Mol Biol Cell. 2024. PMID: 38446639 Free PMC article.
Excess dietary sodium partially restores salt and water homeostasis caused by loss of the endoplasmic reticulum molecular chaperone, GRP170, in the mouse nephron.
Porter A, Vorndran HE, Marciszyn A, Mutchler SM, Subramanya AR, Kleyman TR, Hendershot LM, Brodsky JL, Buck TM. Porter A, et al. Among authors: vorndran he. bioRxiv [Preprint]. 2024 Jan 14:2024.01.13.575426. doi: 10.1101/2024.01.13.575426. bioRxiv. 2024. Update in: Am J Physiol Renal Physiol. 2025 Feb 1;328(2):F173-F189. doi: 10.1152/ajprenal.00192.2024 PMID: 38260467 Free PMC article. Updated. Preprint.
Lhs1 dependent ERAD is determined by transmembrane domain context.
Sukhoplyasova M, Keith AM, Perrault EM, Vorndran HE, Jordahl AS, Yates ME, Pastor A, Li Z, Freaney ML, Deshpande RA, Adams DB, Guerriero CJ, Shi S, Kleyman TR, Kashlan OB, Brodsky JL, Buck TM. Sukhoplyasova M, et al. Among authors: vorndran he. Biochem J. 2023 Sep 27;480(18):1459-1473. doi: 10.1042/BCJ20230075. Biochem J. 2023. PMID: 37702403 Free PMC article.