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Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity.
Gao W, Liu L, Huh E, Gbahou F, Cecon E, Oshima M, Houzé L, Katsonis P, Hegron A, Fan Z, Hou G, Charpentier G, Boissel M, Derhourhi M, Marre M, Balkau B, Froguel P, Scharfmann R, Lichtarge O, Dam J, Bonnefond A, Liu J, Jockers R. Gao W, et al. Among authors: balkau b. Nat Metab. 2023 Oct;5(10):1673-1684. doi: 10.1038/s42255-023-00889-6. Epub 2023 Sep 14. Nat Metab. 2023. PMID: 37709961 Free PMC article.
The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study.
Jaziri R, Lobbens S, Aubert R, Péan F, Lahmidi S, Vaxillaire M, Porchay I, Bellili N, Tichet J, Balkau B, Froguel P, Marre M, Fumeron F; DESIR Study Group. Jaziri R, et al. Among authors: balkau b. Diabetes. 2006 Apr;55(4):1157-62. doi: 10.2337/diabetes.55.04.06.db05-0676. Diabetes. 2006. PMID: 16567542
597 results