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Page 1
Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.
Hollinshead KER, Munford H, Eales KL, Bardella C, Li C, Escribano-Gonzalez C, Thakker A, Nonnenmacher Y, Kluckova K, Jeeves M, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson DJ, Hua W, Tomlinson IP, Ludwig C, Mao Y, Tennant DA. Hollinshead KER, et al. Among authors: tennant da. Cell Rep. 2018 Mar 20;22(12):3107-3114. doi: 10.1016/j.celrep.2018.02.084. Cell Rep. 2018. PMID: 29562167 Free PMC article.
Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions.
Westbrook RL, Bridges E, Roberts J, Escribano-Gonzalez C, Eales KL, Vettore LA, Walker PD, Vera-Siguenza E, Rana H, Cuozzo F, Eskla KL, Vellama H, Shaaban A, Nixon C, Luuk H, Lavery GG, Hodson DJ, Harris AL, Tennant DA. Westbrook RL, et al. Among authors: tennant da. Cell Rep. 2022 Feb 1;38(5):110320. doi: 10.1016/j.celrep.2022.110320. Cell Rep. 2022. PMID: 35108535 Free PMC article.
Uptake of long-chain fatty acids from the bone marrow suppresses CD8+ T-cell metabolism and function in multiple myeloma.
Gudgeon N, Giles H, Bishop EL, Fulton-Ward T, Escribano-Gonzalez C, Munford H, James-Bott A, Foster K, Karim F, Jayawardana D, Mahmood A, Cribbs AP, Tennant DA, Basu S, Pratt G, Dimeloe S. Gudgeon N, et al. Among authors: tennant da. Blood Adv. 2023 Oct 24;7(20):6035-6047. doi: 10.1182/bloodadvances.2023009890. Blood Adv. 2023. PMID: 37276076 Free PMC article.
Hypoxia and metabolic adaptation of cancer cells.
Eales KL, Hollinshead KE, Tennant DA. Eales KL, et al. Among authors: tennant da. Oncogenesis. 2016 Jan 25;5(1):e190. doi: 10.1038/oncsis.2015.50. Oncogenesis. 2016. PMID: 26807645 Free PMC article. Review.
Metabolic transformation in cancer.
Tennant DA, Durán RV, Boulahbel H, Gottlieb E. Tennant DA, et al. Carcinogenesis. 2009 Aug;30(8):1269-80. doi: 10.1093/carcin/bgp070. Epub 2009 Mar 25. Carcinogenesis. 2009. PMID: 19321800 Review.
A roadmap for interpreting (13)C metabolite labeling patterns from cells.
Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM. Buescher JM, et al. Among authors: tennant da. Curr Opin Biotechnol. 2015 Aug;34:189-201. doi: 10.1016/j.copbio.2015.02.003. Epub 2015 Feb 28. Curr Opin Biotechnol. 2015. PMID: 25731751 Free PMC article. Review.
179 results