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Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro.
Zhang Q, Chen CZ, Swaroop M, Xu M, Wang L, Lee J, Wang AQ, Pradhan M, Hagen N, Chen L, Shen M, Luo Z, Xu X, Xu Y, Huang W, Zheng W, Ye Y. Zhang Q, et al. bioRxiv [Preprint]. 2020 Sep 18:2020.07.14.202549. doi: 10.1101/2020.07.14.202549. bioRxiv. 2020. Update in: Cell Discov. 2020 Nov 4;6(1):80. doi: 10.1038/s41421-020-00222-5 PMID: 32699847 Free PMC article. Updated. Preprint.
Heparan sulfate promotes ACE2 super-cluster assembly to enhance SARS-CoV-2-associated syncytium formation.
Zhang Q, Tang WC, Stancanelli E, Jung E, Syed Z, Pagadala V, Saidi L, Chen CZ, Gao P, Xu M, Pavlinov I, Li B, Huang W, Chen L, Liu J, Xie H, Zheng W, Ye Y. Zhang Q, et al. Res Sq [Preprint]. 2023 Mar 28:rs.3.rs-2693563. doi: 10.21203/rs.3.rs-2693563/v1. Res Sq. 2023. Update in: Nat Commun. 2023 Sep 18;14(1):5777. doi: 10.1038/s41467-023-41453-w PMID: 37034606 Free PMC article. Updated. Preprint.
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