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Page 1
Pervasive mislocalization of pathogenic coding variants underlying human disorders.
Lacoste J, Haghighi M, Haider S, Lin ZY, Segal D, Reno C, Qian WW, Xiong X, Shafqat-Abbasi H, Ryder PV, Senft R, Cimini BA, Roth FP, Calderwood M, Hill D, Vidal M, Yi SS, Sahni N, Peng J, Gingras AC, Singh S, Carpenter AE, Taipale M. Lacoste J, et al. bioRxiv [Preprint]. 2023 Sep 5:2023.09.05.556368. doi: 10.1101/2023.09.05.556368. bioRxiv. 2023. Update in: Cell. 2024 Nov 14;187(23):6725-6741.e13. doi: 10.1016/j.cell.2024.09.003 PMID: 37732209 Free PMC article. Updated. Preprint.
A central chaperone-like role for 14-3-3 proteins in human cells.
Segal D, Maier S, Mastromarco GJ, Qian WW, Nabeel-Shah S, Lee H, Moore G, Lacoste J, Larsen B, Lin ZY, Selvabaskaran A, Liu K, Smibert C, Zhang Z, Greenblatt J, Peng J, Lee HO, Gingras AC, Taipale M. Segal D, et al. Among authors: lacoste j. Mol Cell. 2023 Mar 16;83(6):974-993.e15. doi: 10.1016/j.molcel.2023.02.018. Mol Cell. 2023. PMID: 36931259 Free article.
Proteome-scale discovery of protein degradation and stabilization effectors.
Poirson J, Cho H, Dhillon A, Haider S, Imrit AZ, Lam MHY, Alerasool N, Lacoste J, Mizan L, Wong C, Gingras AC, Schramek D, Taipale M. Poirson J, et al. Among authors: lacoste j. Nature. 2024 Apr;628(8009):878-886. doi: 10.1038/s41586-024-07224-3. Epub 2024 Mar 20. Nature. 2024. PMID: 38509365
Pervasive mislocalization of pathogenic coding variants underlying human disorders.
Lacoste J, Haghighi M, Haider S, Reno C, Lin ZY, Segal D, Qian WW, Xiong X, Teelucksingh T, Miglietta E, Shafqat-Abbasi H, Ryder PV, Senft R, Cimini BA, Murray RR, Nyirakanani C, Hao T, McClain GG, Roth FP, Calderwood MA, Hill DE, Vidal M, Yi SS, Sahni N, Peng J, Gingras AC, Singh S, Carpenter AE, Taipale M. Lacoste J, et al. Cell. 2024 Nov 14;187(23):6725-6741.e13. doi: 10.1016/j.cell.2024.09.003. Epub 2024 Sep 30. Cell. 2024. PMID: 39353438
A conformational switch driven by phosphorylation regulates the activity of the evolutionarily conserved SNARE Ykt6.
McGrath K, Agarwal S, Tonelli M, Dergai M, Gaeta AL, Shum AK, Lacoste J, Zhang Y, Wen W, Chung D, Wiersum G, Shevade A, Zaichick S, van Rossum DB, Shuvalova L, Savas JN, Kuchin S, Taipale M, Caldwell KA, Caldwell GA, Fasshauer D, Caraveo G. McGrath K, et al. Among authors: lacoste j. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2016730118. doi: 10.1073/pnas.2016730118. Proc Natl Acad Sci U S A. 2021. PMID: 33723042 Free PMC article.
285 results