Schwank G - Search Results

1

Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility.

Schmidheini L, Mathis N, Marquart KF, Rothgangl T, Kissling L, Böck D, Chanez C, Wang JP, Jinek M, Schwank G. Schmidheini L, et al. Among authors: schwank g. Nat Chem Biol. 2024 Mar;20(3):333-343. doi: 10.1038/s41589-023-01427-x. Epub 2023 Sep 21. Nat Chem Biol. 2024. PMID: 37735239 Free PMC article.

2

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ.

Farin HF, Karthaus WR, Kujala P, Rakhshandehroo M, Schwank G, Vries RG, Kalkhoven E, Nieuwenhuis EE, Clevers H. Farin HF, et al. Among authors: schwank g. J Exp Med. 2014 Jun 30;211(7):1393-405. doi: 10.1084/jem.20130753. J Exp Med. 2014. PMID: 24980747 Free PMC article.

3

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.

Schwank G, Koo BK, Sasselli V, Dekkers JF, Heo I, Demircan T, Sasaki N, Boymans S, Cuppen E, van der Ent CK, Nieuwenhuis EE, Beekman JM, Clevers H. Schwank G, et al. Cell Stem Cell. 2013 Dec 5;13(6):653-8. doi: 10.1016/j.stem.2013.11.002. Cell Stem Cell. 2013. PMID: 24315439 Free article.

4

Generation of BAC transgenic epithelial organoids.

Schwank G, Andersson-Rolf A, Koo BK, Sasaki N, Clevers H. Schwank G, et al. PLoS One. 2013 Oct 18;8(10):e76871. doi: 10.1371/journal.pone.0076871. eCollection 2013. PLoS One. 2013. PMID: 24204693 Free PMC article.

5

Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels.

Schwank G, Restrepo S, Basler K. Schwank G, et al. Development. 2008 Dec;135(24):4003-13. doi: 10.1242/dev.025635. Development. 2008. PMID: 19029041 Free article.

6

Auxin triggers transient local signaling for cell specification in Arabidopsis embryogenesis.

Weijers D, Schlereth A, Ehrismann JS, Schwank G, Kientz M, Jürgens G. Weijers D, et al. Among authors: schwank g. Dev Cell. 2006 Feb;10(2):265-70. doi: 10.1016/j.devcel.2005.12.001. Dev Cell. 2006. PMID: 16459305 Free article.

7

Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair.

Savic N, Ringnalda FC, Lindsay H, Berk C, Bargsten K, Li Y, Neri D, Robinson MD, Ciaudo C, Hall J, Jinek M, Schwank G. Savic N, et al. Among authors: schwank g. Elife. 2018 May 29;7:e33761. doi: 10.7554/eLife.33761. Elife. 2018. PMID: 29809142 Free PMC article.

8

In vitro Generation of CRISPR-Cas9 Complexes with Covalently Bound Repair Templates for Genome Editing in Mammalian Cells.

Savić N, Ringnalda FC, Berk C, Bargsten K, Hall J, Jinek M, Schwank G. Savić N, et al. Among authors: schwank g. Bio Protoc. 2019 Jan 5;9(1):e3136. doi: 10.21769/BioProtoc.3136. Bio Protoc. 2019. PMID: 30675496 Free PMC article.

9

In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA.

Villiger L, Rothgangl T, Witzigmann D, Oka R, Lin PJC, Qi W, Janjuha S, Berk C, Ringnalda F, Beattie MB, Stoffel M, Thöny B, Hall J, Rehrauer H, van Boxtel R, Tam YK, Schwank G. Villiger L, et al. Among authors: schwank g. Nat Biomed Eng. 2021 Feb;5(2):179-189. doi: 10.1038/s41551-020-00671-z. Epub 2021 Jan 25. Nat Biomed Eng. 2021. PMID: 33495639 Free PMC article.

10

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels.

Rothgangl T, Dennis MK, Lin PJC, Oka R, Witzigmann D, Villiger L, Qi W, Hruzova M, Kissling L, Lenggenhager D, Borrelli C, Egli S, Frey N, Bakker N, Walker JA 2nd, Kadina AP, Victorov DV, Pacesa M, Kreutzer S, Kontarakis Z, Moor A, Jinek M, Weissman D, Stoffel M, van Boxtel R, Holden K, Pardi N, Thöny B, Häberle J, Tam YK, Semple SC, Schwank G. Rothgangl T, et al. Among authors: schwank g. Nat Biotechnol. 2021 Aug;39(8):949-957. doi: 10.1038/s41587-021-00933-4. Epub 2021 May 19. Nat Biotechnol. 2021. PMID: 34012094 Free PMC article.

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