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Discovery of HZS60 as a Novel Brain Penetrant NMDAR/TRPM4 Interaction Interface Inhibitor with Improved Activity and Pharmacokinetic Properties for the Treatment of Cerebral Ischemia.
Sun M, Wang L, Cao Q, Wang X, Zhang Y, Guo M, Chen J, Ma Y, Niu L, Zhang Y, Hu M, Gu M, Zhu Z, Yao X, Yao J, Zhao C, Wu J, Liu X, Lu Y, Wang Z, Xiang Q, Han F, Zhu D. Sun M, et al. Among authors: zhang y. J Med Chem. 2025 Jan 2. doi: 10.1021/acs.jmedchem.4c02772. Online ahead of print. J Med Chem. 2025. PMID: 39745498
Characteristics of viral ovarian tumor domain protease from two emerging orthonairoviruses and identification of Yezo virus human infections in northeastern China as early as 2012.
Chen Z-Y, Zhang J, He P-J, Xiong T, Zhu D-Y, Zhu W-J, Ni X-B, Du L-F, Wang Q, Zhang Y-W, Xia L-Y, Chen D-S, Li L-J, Zhang M-Z, Cui XM, Wang T-H, Wang J, Wang Z, An T-F, Cao W-C, Liu X-H, Huang E-J, Jia N. Chen Z-Y, et al. Among authors: zhang y w. J Virol. 2024 Dec 31:e0172724. doi: 10.1128/jvi.01727-24. Online ahead of print. J Virol. 2024. PMID: 39745436
Highly Diastereoselective Access to Densely Functionalized Piperidine Cores of Influenza Endonuclease Inhibitors via a Metal-Free SN1 Approach.
Zhang Y, Sun C, Guo L, Zhao K, Bennett F, Lam YH, Gao Q, Ruhl KE, Pirnot MT, Emmert MH, Hollenstein K, Eddins MJ, Su HP, Shao G, Song C, Lo MM, Peng F, Qi J, Crowley BM, McCauley JA, Price IR. Zhang Y, et al. J Org Chem. 2025 Jan 2. doi: 10.1021/acs.joc.4c02379. Online ahead of print. J Org Chem. 2025. PMID: 39745425
260,389 results
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