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Page 1
Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor.
Burghi V, Paradis JS, Officer A, Adame-Garcia SR, Wu X, Matthees ESF, Barsi-Rhyne B, Ramms DJ, Clubb L, Acosta M, Tamayo P, Bouvier M, Inoue A, von Zastrow M, Hoffmann C, Gutkind JS. Burghi V, et al. Among authors: adame garcia sr. J Biol Chem. 2023 Nov;299(11):105293. doi: 10.1016/j.jbc.2023.105293. Epub 2023 Sep 27. J Biol Chem. 2023. PMID: 37774973 Free PMC article.
Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC).
Rigiracciolo DC, Nohata N, Lappano R, Cirillo F, Talia M, Adame-Garcia SR, Arang N, Lubrano S, De Francesco EM, Belfiore A, Gutkind JS, Maggiolini M. Rigiracciolo DC, et al. Among authors: adame garcia sr. J Exp Clin Cancer Res. 2022 Jun 3;41(1):193. doi: 10.1186/s13046-022-02396-0. J Exp Clin Cancer Res. 2022. PMID: 35655319 Free PMC article.
Gβγ recruits and activates P-Rex1 via two independent binding interfaces.
Cervantes-Villagrana RD, Beltrán-Navarro YM, García-Jiménez I, Adame-García SR, Olguín-Olguín A, Reyes-Cruz G, Vázquez-Prado J. Cervantes-Villagrana RD, et al. Among authors: adame garcia sr. Biochem Biophys Res Commun. 2021 Feb 5;539:20-27. doi: 10.1016/j.bbrc.2020.12.089. Epub 2021 Jan 4. Biochem Biophys Res Commun. 2021. PMID: 33412417
Gαs directly drives PDZ-RhoGEF signaling to Cdc42.
Castillo-Kauil A, García-Jiménez I, Cervantes-Villagrana RD, Adame-García SR, Beltrán-Navarro YM, Gutkind JS, Reyes-Cruz G, Vázquez-Prado J. Castillo-Kauil A, et al. Among authors: adame garcia sr. J Biol Chem. 2020 Dec 11;295(50):16920-16928. doi: 10.1074/jbc.AC120.015204. Epub 2020 Oct 6. J Biol Chem. 2020. PMID: 33023908 Free PMC article.
Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins.
Cervantes-Villagrana RD, Adame-García SR, García-Jiménez I, Color-Aparicio VM, Beltrán-Navarro YM, König GM, Kostenis E, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J. Cervantes-Villagrana RD, et al. Among authors: adame garcia sr. J Biol Chem. 2019 Jan 11;294(2):531-546. doi: 10.1074/jbc.RA118.006254. Epub 2018 Nov 16. J Biol Chem. 2019. PMID: 30446620 Free PMC article.
VPS28, an ESCRT-I protein, regulates mitotic spindle organization via Gβγ, EG5 and TPX2.
Dionisio-Vicuña MN, Gutiérrez-López TY, Adame-García SR, Vázquez-Prado J, Reyes-Cruz G. Dionisio-Vicuña MN, et al. Among authors: adame garcia sr. Biochim Biophys Acta Mol Cell Res. 2018 Jul;1865(7):1012-1022. doi: 10.1016/j.bbamcr.2018.03.005. Epub 2018 Mar 14. Biochim Biophys Acta Mol Cell Res. 2018. PMID: 29548937 Free article. No abstract available.
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