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Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor.
Burghi V, Paradis JS, Officer A, Adame-Garcia SR, Wu X, Matthees ESF, Barsi-Rhyne B, Ramms DJ, Clubb L, Acosta M, Tamayo P, Bouvier M, Inoue A, von Zastrow M, Hoffmann C, Gutkind JS. Burghi V, et al. Among authors: gutkind js. J Biol Chem. 2023 Nov;299(11):105293. doi: 10.1016/j.jbc.2023.105293. Epub 2023 Sep 27. J Biol Chem. 2023. PMID: 37774973 Free PMC article.
The landscape of cancer rewired GPCR signaling axes.
Arora C, Matic M, DiChiaro P, Rosa NO, Carli F, Clubb L, Fard LAN, Kargas G, Diaferia G, Vukotic R, Licata L, Wu G, Natoli G, Gutkind JS, Raimondi F. Arora C, et al. Among authors: gutkind js. bioRxiv [Preprint]. 2023 Oct 11:2023.03.13.532291. doi: 10.1101/2023.03.13.532291. bioRxiv. 2023. Update in: Cell Genom. 2024 May 8;4(5):100557. doi: 10.1016/j.xgen.2024.100557 PMID: 37398064 Free PMC article. Updated. Preprint.
Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch.
Bracho-Valdés I, Cervantes-Villagrana RD, Beltrán-Navarro YM, Olguín-Olguín A, Escobar-Islas E, Carretero-Ortega J, Olivares-Reyes JA, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J. Bracho-Valdés I, et al. Among authors: gutkind js. Int J Mol Sci. 2023 Dec 15;24(24):17531. doi: 10.3390/ijms242417531. Int J Mol Sci. 2023. PMID: 38139359 Free PMC article.
A genome-wide CRISPR screen reveals that antagonism of glutamine metabolism sensitizes head and neck squamous cell carcinoma to ferroptotic cell death.
Allevato MM, Trinh S, Koshizuka K, Nachmanson D, Nguyen TC, Yokoyama Y, Wu X, Andres A, Wang Z, Watrous J, Molinolo AA, Mali P, Harismendy O, Jain M, Wild R, Gutkind JS. Allevato MM, et al. Among authors: gutkind js. Cancer Lett. 2024 Aug 28;598:217089. doi: 10.1016/j.canlet.2024.217089. Epub 2024 Jul 2. Cancer Lett. 2024. PMID: 38964731
546 results