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Negative feedback regulation of MAPK signaling is an important driver of chronic lymphocytic leukemia progression.
Ecker V, Brandmeier L, Stumpf M, Giansanti P, Moreira AV, Pfeuffer L, Fens MHAM, Lu J, Kuster B, Engleitner T, Heidegger S, Rad R, Ringshausen I, Zenz T, Wendtner CM, Müschen M, Jellusova J, Ruland J, Buchner M. Ecker V, et al. Among authors: ruland j. Cell Rep. 2023 Oct 31;42(10):113017. doi: 10.1016/j.celrep.2023.113017. Epub 2023 Oct 4. Cell Rep. 2023. PMID: 37792532 Free article.
Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy.
Heidegger S, Stritzke F, Dahl S, Daßler-Plenker J, Joachim L, Buschmann D, Fan K, Sauer CM, Ludwig N, Winter C, Enssle S, Li S, Perl M, Görgens A, Haas T, Orberg ET, Göttert S, Wölfel C, Engleitner T, Cortés-Ciriano I, Rad R, Herr W, Giebel B, Ruland J, Bassermann F, Coch C, Hartmann G, Poeck H. Heidegger S, et al. Among authors: ruland j. Cell Rep Med. 2023 Sep 19;4(9):101171. doi: 10.1016/j.xcrm.2023.101171. Epub 2023 Aug 31. Cell Rep Med. 2023. PMID: 37657445 Free PMC article.
The microbial metabolite desaminotyrosine enhances T-cell priming and cancer immunotherapy with immune checkpoint inhibitors.
Joachim L, Göttert S, Sax A, Steiger K, Neuhaus K, Heinrich P, Fan K, Orberg ET, Kleigrewe K, Ruland J, Bassermann F, Herr W, Posch C, Heidegger S, Poeck H. Joachim L, et al. Among authors: ruland j. EBioMedicine. 2023 Nov;97:104834. doi: 10.1016/j.ebiom.2023.104834. Epub 2023 Oct 20. EBioMedicine. 2023. PMID: 37865045 Free PMC article.
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors.
Reinecke M, Brear P, Vornholz L, Berger BT, Seefried F, Wilhelm S, Samaras P, Gyenis L, Litchfield DW, Médard G, Müller S, Ruland J, Hyvönen M, Wilhelm M, Kuster B. Reinecke M, et al. Among authors: ruland j. Nat Chem Biol. 2024 May;20(5):577-585. doi: 10.1038/s41589-023-01459-3. Epub 2023 Oct 30. Nat Chem Biol. 2024. PMID: 37904048 Free PMC article.
T Cells Directed against the Metastatic Driver Chondromodulin-1 in Ewing Sarcoma: Comparative Engineering with CRISPR/Cas9 vs. Retroviral Gene Transfer for Adoptive Transfer.
Xue B, von Heyking K, Gassmann H, Poorebrahim M, Thiede M, Schober K, Mautner J, Hauer J, Ruland J, Busch DH, Thiel U, Burdach SEG. Xue B, et al. Among authors: ruland j. Cancers (Basel). 2022 Nov 8;14(22):5485. doi: 10.3390/cancers14225485. Cancers (Basel). 2022. PMID: 36428578 Free PMC article.
B cell-mediated CD4 T-cell costimulation via CD86 exacerbates pro-inflammatory cytokine production during autoimmune intestinal inflammation.
Gadjalova I, Heinze JM, Goess MC, Hofmann J, Buck A, Weber MC, Blissenbach B, Kampick M, Krut O, Steiger K, Janssen KP, Neumann PA, Ruland J, Keppler SJ. Gadjalova I, et al. Among authors: ruland j. Mucosal Immunol. 2024 Feb;17(1):67-80. doi: 10.1016/j.mucimm.2023.10.005. Epub 2023 Oct 31. Mucosal Immunol. 2024. PMID: 37918715 Free article.
Platelet mass cytometry reveals dysregulation of prothrombotic pathways in essential thrombocythemia.
Dill V, Kirmes K, Han J, Klug M, Rosenbaum M, Viggiani G, von Scheidt M, List M, Herhaus P, Ruland J, Bassermann F, Laugwitz KL, Götze KS, Jost PJ, Jilg S, Bloxham CJ, Raake PWJ, Bernlochner I, Bongiovanni D. Dill V, et al. Among authors: ruland j. Platelets. 2024 Dec;35(1):2358244. doi: 10.1080/09537104.2024.2358244. Epub 2024 Jun 7. Platelets. 2024. PMID: 38845541 Free article.
224 results