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Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity.
Tedbury PR, Manfredi C, Degenhardt F, Conway J, Horwath MC, McCracken C, Sorscher AJ, Moreau S, Wright C, Edwards C, Brewer J, Guarner J, de Wit E, Williamson BN, Suthar MS, Ong YT, Roback JD, Alter DN, Holter JC, Karlsen TH, Sacchi N, Romero-Gómez M, Invernizzi P, Fernández J, Buti M, Albillos A, Julià A, Valenti L, Asselta R, Banales JM, Bujanda L, de Cid R, Franke A; Severe COVID-19 GWAS group; Sarafianos SG, Hong JS, Sorscher EJ, Ehrhardt A. Tedbury PR, et al. Among authors: manfredi c. FASEB J. 2023 Nov;37(11):e23220. doi: 10.1096/fj.202300077R. FASEB J. 2023. PMID: 37801035 Free PMC article.
Making precision medicine personal for cystic fibrosis.
Manfredi C, Tindall JM, Hong JS, Sorscher EJ. Manfredi C, et al. Science. 2019 Jul 19;365(6450):220-221. doi: 10.1126/science.aaw0553. Science. 2019. PMID: 31320522 Free PMC article. No abstract available.
Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures.
Vanderheiden A, Ralfs P, Chirkova T, Upadhyay AA, Zimmerman MG, Bedoya S, Aoued H, Tharp GM, Pellegrini KL, Manfredi C, Sorscher E, Mainou B, Lobby JL, Kohlmeier JE, Lowen AC, Shi PY, Menachery VD, Anderson LJ, Grakoui A, Bosinger SE, Suthar MS. Vanderheiden A, et al. Among authors: manfredi c. J Virol. 2020 Sep 15;94(19):e00985-20. doi: 10.1128/JVI.00985-20. Print 2020 Sep 15. J Virol. 2020. PMID: 32699094 Free PMC article.
Marine Natural Products as Leads against SARS-CoV-2 Infection.
Chhetri BK, Tedbury PR, Sweeney-Jones AM, Mani L, Soapi K, Manfredi C, Sorscher E, Sarafianos SG, Kubanek J. Chhetri BK, et al. Among authors: manfredi c. J Nat Prod. 2022 Mar 25;85(3):657-665. doi: 10.1021/acs.jnatprod.2c00015. Epub 2022 Mar 15. J Nat Prod. 2022. PMID: 35290044 Free PMC article.
Engineered tRNAs suppress nonsense mutations in cells and in vivo.
Albers S, Allen EC, Bharti N, Davyt M, Joshi D, Perez-Garcia CG, Santos L, Mukthavaram R, Delgado-Toscano MA, Molina B, Kuakini K, Alayyoubi M, Park KJ, Acharya G, Gonzalez JA, Sagi A, Birket SE, Tearney GJ, Rowe SM, Manfredi C, Hong JS, Tachikawa K, Karmali P, Matsuda D, Sorscher EJ, Chivukula P, Ignatova Z. Albers S, et al. Among authors: manfredi c. Nature. 2023 Jun;618(7966):842-848. doi: 10.1038/s41586-023-06133-1. Epub 2023 May 31. Nature. 2023. PMID: 37258671 Free PMC article.
A Novel 7H-[1,2,4]Triazolo[3,4-b]thiadiazine-based Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Directed toward Treatment of Cystic Fibrosis.
Rab A, Yang X, Tracy WF, Hong JS, Joshi D, Manfredi C, Ponnaluri SS, Kolykhalov AA, Qui M, Fu H, Du Y, Davies HML, Sorscher EJ. Rab A, et al. Among authors: manfredi c. ACS Med Chem Lett. 2023 Sep 20;14(10):1338-1343. doi: 10.1021/acsmedchemlett.3c00155. eCollection 2023 Oct 12. ACS Med Chem Lett. 2023. PMID: 37849531 Free PMC article.
Evaluation of elexacaftor-tezacaftor-ivacaftor treatment in individuals with cystic fibrosis and CFTRN1303K in the USA: a prospective, multicentre, open-label, single-arm trial.
Solomon GM, Linnemann RW, Rich R, Streby A, Buehler B, Hunter E, Vijaykumar K, Hunt WR, Brewington JJ, Rab A, Bai SP, Westbrook AL, McNicholas-Bevensee C, Hong J, Manfredi C, Barilla C, Suzuki S, Davis BR, Sorscher EJ. Solomon GM, et al. Among authors: manfredi c. Lancet Respir Med. 2024 Dec;12(12):947-957. doi: 10.1016/S2213-2600(24)00205-4. Epub 2024 Aug 26. Lancet Respir Med. 2024. PMID: 39208836
Development of robust antiviral assays using relevant apical-out human airway organoids.
Lee JH, LeCher JC, Parigoris E, Shinagawa N, Sentosa J, Manfredi C, Goh SL, De R, Tao S, Zandi K, Amblard F, Sorscher EJ, Spence JR, Tirouvanziam R, Schinazi RF, Takayama S. Lee JH, et al. Among authors: manfredi c. bioRxiv [Preprint]. 2024 Jul 12:2024.01.02.573939. doi: 10.1101/2024.01.02.573939. bioRxiv. 2024. PMID: 38260306 Free PMC article. Preprint.
The Correlation Between Body Mass Index and Prostate Volume: A Retrospective Analysis of Pre and Postoperative Measurements in Prostate Cancer Patients.
Barone B, Amicuzi U, Massanova M, Napolitano L, Reccia P, Mirto BF, Balsamo R, Giudice FD, Ferro M, Busetto GM, Tataru OS, Lucarelli G, Manfredi C, Biondo DD, Caputo VF, Falabella R, Fusco F, Imbimbo C, Crocetto F. Barone B, et al. Among authors: manfredi c. Prostate. 2024 Dec 23. doi: 10.1002/pros.24845. Online ahead of print. Prostate. 2024. PMID: 39716024
375 results