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Page 1
Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomics.
Rexach JE, Cheng Y, Chen L, Polioudakis D, Lin LC, Mitri V, Elkins A, Yin A, Calini D, Kawaguchi R, Ou J, Huang J, Williams C, Robinson J, Gaus SE, Spina S, Lee EB, Grinberg LT, Vinters H, Trojanowski JQ, Seeley WW, Malhotra D, Geschwind DH. Rexach JE, et al. Among authors: kawaguchi r. bioRxiv [Preprint]. 2023 Sep 30:2023.09.29.560245. doi: 10.1101/2023.09.29.560245. bioRxiv. 2023. Update in: Cell. 2024 Oct 3;187(20):5753-5774.e28. doi: 10.1016/j.cell.2024.08.019 PMID: 37808727 Free PMC article. Updated. Preprint.
Molecular cascades and cell-type specific signatures in ASD revealed by single cell genomics.
Wamsley B, Bicks L, Cheng Y, Kawaguchi R, Quintero D, Grundman J, Liu J, Xiao S, Hawken N, Margolis M, Mazariegos S, Geschwind DH. Wamsley B, et al. Among authors: kawaguchi r. bioRxiv [Preprint]. 2023 Mar 10:2023.03.10.530869. doi: 10.1101/2023.03.10.530869. bioRxiv. 2023. Update in: Science. 2024 May 24;384(6698):eadh2602. doi: 10.1126/science.adh2602 PMID: 36945369 Free PMC article. Updated. Preprint.
Brain-wide neuronal circuit connectome of human glioblastoma.
Sun Y, Wang X, Zhang DY, Zhang Z, Bhattarai JP, Wang Y, Dong W, Zhang F, Park KH, Galanaugh J, Sambangi A, Yang Q, Kim SH, Wheeler G, Goncalves T, Wang Q, Geschwind D, Kawaguchi R, Wang H, Xu F, Binder ZA, Chen IH, Pai EL, Stone S, Nasrallah M, Christian KM, Fuccillo M, O'Rourke DM, Ma M, Ming GL, Song H. Sun Y, et al. Among authors: kawaguchi r. bioRxiv [Preprint]. 2024 Mar 4:2024.03.01.583047. doi: 10.1101/2024.03.01.583047. bioRxiv. 2024. PMID: 38496540 Free PMC article. Preprint.
Sarm1 is not necessary for activation of neuron-intrinsic growth programs yet required for the Schwann cell repair response and peripheral nerve regeneration.
Schmitd LB, Hafner H, Ward A, Asghari Adib E, Biscola NP, Kohen R, Patel M, Williamson RE, Desai E, Bennett J, Saxman G, Athaiya M, Wilborn D, Shumpert J, Zhao XF, Kawaguchi R, Geschwind DH, Hoke A, Shrager P, Collins CA, Havton LA, Kalinski AL, Giger RJ. Schmitd LB, et al. Among authors: kawaguchi r. bioRxiv [Preprint]. 2024 Apr 17:2024.03.04.583374. doi: 10.1101/2024.03.04.583374. bioRxiv. 2024. PMID: 38496662 Free PMC article. Preprint.
Single-cell genomics and regulatory networks for 388 human brains.
Emani PS, Liu JJ, Clarke D, Jensen M, Warrell J, Gupta C, Meng R, Lee CY, Xu S, Dursun C, Lou S, Chen Y, Chu Z, Galeev T, Hwang A, Li Y, Ni P, Zhou X; PsychENCODE Consortium; Bakken TE, Bendl J, Bicks L, Chatterjee T, Cheng L, Cheng Y, Dai Y, Duan Z, Flaherty M, Fullard JF, Gancz M, Garrido-Martín D, Gaynor-Gillett S, Grundman J, Hawken N, Henry E, Hoffman GE, Huang A, Jiang Y, Jin T, Jorstad NL, Kawaguchi R, Khullar S, Liu J, Liu J, Liu S, Ma S, Margolis M, Mazariegos S, Moore J, Moran JR, Nguyen E, Phalke N, Pjanic M, Pratt H, Quintero D, Rajagopalan AS, Riesenmy TR, Shedd N, Shi M, Spector M, Terwilliger R, Travaglini KJ, Wamsley B, Wang G, Xia Y, Xiao S, Yang AC, Zheng S, Gandal MJ, Lee D, Lein ES, Roussos P, Sestan N, Weng Z, White KP, Won H, Girgenti MJ, Zhang J, Wang D, Geschwind D, Gerstein M. Emani PS, et al. Among authors: kawaguchi r. bioRxiv [Preprint]. 2024 Mar 30:2024.03.18.585576. doi: 10.1101/2024.03.18.585576. bioRxiv. 2024. Update in: Science. 2024 May 24;384(6698):eadi5199. doi: 10.1126/science.adi5199 PMID: 38562822 Free PMC article. Updated. Preprint.
Intercellular Signaling Pathways as Therapeutic Targets for Vascular Dementia Repair.
Tian M, Kawaguchi R, Shen Y, Machnicki M, Villegas NG, Cooper DR, Montgomery N, Haring J, Lan R, Yuan AH, Williams CK, Magaki S, Vinters HV, Zhang Y, De Biase LM, Silva AJ, Carmichael ST. Tian M, et al. Among authors: kawaguchi r. bioRxiv [Preprint]. 2024 Mar 27:2024.03.24.585301. doi: 10.1101/2024.03.24.585301. bioRxiv. 2024. PMID: 38585718 Free PMC article. Preprint.
Acute rapamycin treatment reveals novel mechanisms of behavioral, physiological, and functional dysfunction in a maternal inflammation mouse model of autism and sensory over-responsivity.
Le Belle JE, Condro M, Cepeda C, Oikonomou KD, Tessema K, Dudley L, Schoenfield J, Kawaguchi R, Geschwind D, Silva AJ, Zhang Z, Shokat K, Harris NG, Kornblum HI. Le Belle JE, et al. Among authors: kawaguchi r. bioRxiv [Preprint]. 2024 Jul 11:2024.07.08.602602. doi: 10.1101/2024.07.08.602602. bioRxiv. 2024. PMID: 39026891 Free PMC article. Preprint.
Lesion-remote astrocytes govern microglia-mediated white matter repair.
McCallum S, Suresh KB, Islam T, Saustad AW, Shelest O, Patil A, Lee D, Kwon B, Yenokian I, Kawaguchi R, Beveridge CH, Manchandra P, Randolph CE, Meares GP, Dutta R, Plummer J, Knott SRV, Chopra G, Burda JE. McCallum S, et al. Among authors: kawaguchi r. bioRxiv [Preprint]. 2024 Mar 17:2024.03.15.585251. doi: 10.1101/2024.03.15.585251. bioRxiv. 2024. PMID: 38558977 Free PMC article. Preprint.
BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice.
Lee CYD, De La Rocha AJ, Inouye K, Langfelder P, Daggett A, Gu X, Jiang LL, Pamonag Z, Vaca RG, Richman J, Kawaguchi R, Gao F, Xu H, Yang XW. Lee CYD, et al. Among authors: kawaguchi r. bioRxiv [Preprint]. 2023 Aug 5:2023.08.03.551881. doi: 10.1101/2023.08.03.551881. bioRxiv. 2023. PMID: 37577582 Free PMC article. Preprint.
A comparative analysis of microglial inducible Cre lines.
Faust TE, Feinberg PA, O'Connor C, Kawaguchi R, Chan A, Strasburger H, Masuda T, Amann L, Knobeloch KP, Prinz M, Schaefer A, Schafer DP. Faust TE, et al. Among authors: kawaguchi r. bioRxiv [Preprint]. 2023 Jan 9:2023.01.09.523268. doi: 10.1101/2023.01.09.523268. bioRxiv. 2023. Update in: Cell Rep. 2023 Sep 26;42(9):113031. doi: 10.1016/j.celrep.2023.113031 PMID: 36711492 Free PMC article. Updated. Preprint.
477 results