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Page 1
Design and testing of a humanized porcine donor for xenotransplantation.
Anand RP, Layer JV, Heja D, Hirose T, Lassiter G, Firl DJ, Paragas VB, Akkad A, Chhangawala S, Colvin RB, Ernst RJ, Esch N, Getchell K, Griffin AK, Guo X, Hall KC, Hamilton P, Kalekar LA, Kan Y, Karadagi A, Li F, Low SC, Matheson R, Nehring C, Otsuka R, Pandelakis M, Policastro RA, Pols R, Queiroz L, Rosales IA, Serkin WT, Stiede K, Tomosugi T, Xue Y, Zentner GE, Angeles-Albores D, Chris Chao J, Crabtree JN, Harken S, Hinkle N, Lemos T, Li M, Pantano L, Stevens D, Subedar OD, Tan X, Yin S, Anwar IJ, Aufhauser D, Capuano S, Kaufman DB, Knechtle SJ, Kwun J, Shanmuganayagam D, Markmann JF, Church GM, Curtis M, Kawai T, Youd ME, Qin W. Anand RP, et al. Among authors: layer jv. Nature. 2023 Oct;622(7982):393-401. doi: 10.1038/s41586-023-06594-4. Epub 2023 Oct 11. Nature. 2023. PMID: 37821590 Free PMC article.
Extensive germline genome engineering in pigs.
Yue Y, Xu W, Kan Y, Zhao HY, Zhou Y, Song X, Wu J, Xiong J, Goswami D, Yang M, Lamriben L, Xu M, Zhang Q, Luo Y, Guo J, Mao S, Jiao D, Nguyen TD, Li Z, Layer JV, Li M, Paragas V, Youd ME, Sun Z, Ding Y, Wang W, Dou H, Song L, Wang X, Le L, Fang X, George H, Anand R, Wang SY, Westlin WF, Güell M, Markmann J, Qin W, Gao Y, Wei HJ, Church GM, Yang L. Yue Y, et al. Among authors: layer jv. Nat Biomed Eng. 2021 Feb;5(2):134-143. doi: 10.1038/s41551-020-00613-9. Epub 2020 Sep 21. Nat Biomed Eng. 2021. PMID: 32958897
Kidney transplantation from triple-knockout pigs expressing multiple human proteins in cynomolgus macaques.
Ma D, Hirose T, Lassiter G, Sasaki H, Rosales I, Coe TM, Rickert CG, Matheson R, Colvin RB, Qin W, Kan Y, Layer JV, Paragas VB, Stiede K, Hall KC, Youd ME, Queiroz LM, Westlin WF, Curtis M, Yang L, Markmann JF, Kawai T. Ma D, et al. Among authors: layer jv. Am J Transplant. 2022 Jan;22(1):46-57. doi: 10.1111/ajt.16780. Epub 2021 Aug 31. Am J Transplant. 2022. PMID: 34331749 Free PMC article.
Genetic modifications designed for xenotransplantation attenuate sialoadhesin-dependent binding of human erythrocytes to porcine macrophages.
Petitpas K, Habibabady Z, Ritchie V, Connolly MR, Burdorf L, Qin W, Kan Y, Layer JV, Crabtree JN, Youd ME, Westlin WF, Magnani DM, Pierson RN 3rd, Azimzadeh AM. Petitpas K, et al. Among authors: layer jv. Xenotransplantation. 2022 Nov;29(6):e12780. doi: 10.1111/xen.12780. Epub 2022 Sep 20. Xenotransplantation. 2022. PMID: 36125388 Free PMC article.
PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA.
Day TA, Layer JV, Cleary JP, Guha S, Stevenson KE, Tivey T, Kim S, Schinzel AC, Izzo F, Doench J, Root DE, Hahn WC, Price BD, Weinstock DM. Day TA, et al. Among authors: layer jv. Nat Commun. 2017 Apr 27;8:15110. doi: 10.1038/ncomms15110. Nat Commun. 2017. PMID: 28447610 Free PMC article.
Corrigendum: PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA.
Day TA, Layer JV, Cleary JP, Guha S, Stevenson KE, Tivey T, Kim S, Schinzel AC, Izzo F, Doench J, Root DE, Hahn WC, Price BD, Weinstock DM. Day TA, et al. Among authors: layer jv. Nat Commun. 2017 Jun 13;8:15918. doi: 10.1038/ncomms15918. Nat Commun. 2017. PMID: 28607496 Free PMC article.
HSP90 inhibition overcomes ibrutinib resistance in mantle cell lymphoma.
Jacobson C, Kopp N, Layer JV, Redd RA, Tschuri S, Haebe S, van Bodegom D, Bird L, Christie AL, Christodoulou A, Saur A, Tivey T, Zapf S, Bararia D, Zimber-Strobl U, Rodig SJ, Weigert O, Weinstock DM. Jacobson C, et al. Among authors: layer jv. Blood. 2016 Nov 24;128(21):2517-2526. doi: 10.1182/blood-2016-04-711176. Epub 2016 Oct 14. Blood. 2016. PMID: 27742706 Free article.
Parp3 promotes long-range end joining in murine cells.
Layer JV, Cleary JP, Brown AJ, Stevenson KE, Morrow SN, Van Scoyk A, Blasco RB, Karaca E, Meng FL, Frock RL, Tivey T, Kim S, Fuchs H, Chiarle R, Alt FW, Roberts SA, Weinstock DM, Day TA. Layer JV, et al. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10076-10081. doi: 10.1073/pnas.1801591115. Epub 2018 Sep 13. Proc Natl Acad Sci U S A. 2018. PMID: 30213852 Free PMC article.
13 results