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A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA.
de Regt AK, Anand K, Ciupka K, Bender F, Gatterdam K, Putschli B, Fusshöller D, Hilbig D, Kirchhoff A, Hunkler C, Wolter S, Grünewald A, Wallerath C, Schuberth-Wagner C, Ludwig J, Paeschke K, Bartok E, Hagelueken G, Hartmann G, Zillinger T, Geyer M, Schlee M. de Regt AK, et al. Among authors: hunkler c. Nucleic Acids Res. 2023 Nov 27;51(21):11893-11910. doi: 10.1093/nar/gkad835. Nucleic Acids Res. 2023. PMID: 37831086 Free PMC article.
RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I.
Kirchhoff A, Herzner AM, Urban C, Piras A, Düster R, Mahlberg J, Grünewald A, Schlee-Guimarães TM, Ciupka K, Leka P, Bootz RJ, Wallerath C, Hunkler C, de Regt AK, Kümmerer BM, Christensen MH, Schmidt FI, Lee-Kirsch MA, Günther C, Kato H, Bartok E, Hartmann G, Geyer M, Pichlmair A, Schlee M. Kirchhoff A, et al. Among authors: hunkler c. EMBO J. 2024 Dec 20. doi: 10.1038/s44318-024-00331-x. Online ahead of print. EMBO J. 2024. PMID: 39707025 Free article.
Observing many researchers using the same data and hypothesis reveals a hidden universe of uncertainty.
Breznau N, Rinke EM, Wuttke A, Nguyen HHV, Adem M, Adriaans J, Alvarez-Benjumea A, Andersen HK, Auer D, Azevedo F, Bahnsen O, Balzer D, Bauer G, Bauer PC, Baumann M, Baute S, Benoit V, Bernauer J, Berning C, Berthold A, Bethke FS, Biegert T, Blinzler K, Blumenberg JN, Bobzien L, Bohman A, Bol T, Bostic A, Brzozowska Z, Burgdorf K, Burger K, Busch KB, Carlos-Castillo J, Chan N, Christmann P, Connelly R, Czymara CS, Damian E, Ecker A, Edelmann A, Eger MA, Ellerbrock S, Forke A, Forster A, Gaasendam C, Gavras K, Gayle V, Gessler T, Gnambs T, Godefroidt A, Grömping M, Groß M, Gruber S, Gummer T, Hadjar A, Heisig JP, Hellmeier S, Heyne S, Hirsch M, Hjerm M, Hochman O, Hövermann A, Hunger S, Hunkler C, Huth N, Ignácz ZS, Jacobs L, Jacobsen J, Jaeger B, Jungkunz S, Jungmann N, Kauff M, Kleinert M, Klinger J, Kolb JP, Kołczyńska M, Kuk J, Kunißen K, Kurti Sinatra D, Langenkamp A, Lersch PM, Löbel LM, Lutscher P, Mader M, Madia JE, Malancu N, Maldonado L, Marahrens H, Martin N, Martinez P, Mayerl J, Mayorga OJ, McManus P, McWagner K, Meeusen C, Meierrieks D, Mellon J, Merhout F, Merk S, Meyer D, Micheli L, Mijs J, Moya C, Neunhoeffer M, Nüst D, Nygård O, Ochsenfeld F, Otte G, Pechen… See abstract for full author list ➔ Breznau N, et al. Among authors: hunkler c. Proc Natl Acad Sci U S A. 2022 Nov;119(44):e2203150119. doi: 10.1073/pnas.2203150119. Epub 2022 Oct 28. Proc Natl Acad Sci U S A. 2022. PMID: 36306328 Free PMC article.
Data Resource Profile: the Survey of Health, Ageing and Retirement in Europe (SHARE).
Börsch-Supan A, Brandt M, Hunkler C, Kneip T, Korbmacher J, Malter F, Schaan B, Stuck S, Zuber S; SHARE Central Coordination Team. Börsch-Supan A, et al. Among authors: hunkler c. Int J Epidemiol. 2013 Aug;42(4):992-1001. doi: 10.1093/ije/dyt088. Epub 2013 Jun 18. Int J Epidemiol. 2013. PMID: 23778574 Free PMC article.