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Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys.
Fenwick C, Turelli P, Duhoo Y, Lau K, Herate C, Marlin R, Lamrayah M, Campos J, Esteves-Leuenberger L, Farina A, Raclot C, Genet V, Fiscalini F, Cesborn J, Perez L, Dereuddre-Bosquet N, Contreras V, Lheureux K, Relouzat F, Abdelnabi R, Leyssen P, Lévy Y, Pojer F, Le Grand R, Trono D, Pantaleo G. Fenwick C, et al. Among authors: le grand r. J Infect. 2023 Dec;87(6):524-537. doi: 10.1016/j.jinf.2023.10.008. Epub 2023 Oct 16. J Infect. 2023. PMID: 37852477 Free article.
Sotrovimab retains activity against SARS-CoV-2 omicron variant BQ.1.1 in a non-human primate model.
Hérate C, Marlin R, Touret F, Dereuddre-Bosquet N, Donati F, Relouzat F, Junges L, Galhaut M, Dehan O, Sconosciuti Q, Nougairède A, de Lamballerie X, van der Werf S, Le Grand R. Hérate C, et al. Among authors: le grand r. Heliyon. 2023 Jun;9(6):e16664. doi: 10.1016/j.heliyon.2023.e16664. Epub 2023 May 30. Heliyon. 2023. PMID: 37287613 Free PMC article.
Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates.
Hermet P, Delache B, Herate C, Wolf E, Kivi G, Juronen E, Mumm K, Žusinaite E, Kainov D, Sankovski E, Virumäe K, Planken A, Merits A, Besaw JE, Yee AW, Morizumi T, Kim K, Kuo A, Berriche A, Dereuddre-Bosquet N, Sconosciuti Q, Naninck T, Relouzat F, Cavarelli M, Ustav M, Wilson D, Ernst OP, Männik A, LeGrand R, Ustav M Jr. Hermet P, et al. PLoS Pathog. 2023 Aug 2;19(8):e1011532. doi: 10.1371/journal.ppat.1011532. eCollection 2023 Aug. PLoS Pathog. 2023. PMID: 37531329 Free PMC article.
Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates.
Marc A, Marlin R, Donati F, Prague M, Kerioui M, Hérate C, Alexandre M, Dereuddre-Bosquet N, Bertrand J, Contreras V, Behillil S, Maisonnasse P, Van Der Werf S, Le Grand R, Guedj J. Marc A, et al. Among authors: le grand r. PLoS Comput Biol. 2023 Aug 9;19(8):e1010721. doi: 10.1371/journal.pcbi.1010721. eCollection 2023 Aug. PLoS Comput Biol. 2023. PMID: 37556476 Free PMC article.
Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses.
Tremain AC, Wallace RP, Lorentz KM, Thornley TB, Antane JT, Raczy MR, Reda JW, Alpar AT, Slezak AJ, Watkins EA, Maulloo CD, Budina E, Solanki A, Nguyen M, Bischoff DJ, Harrington JL, Mishra R, Conley GP, Marlin R, Dereuddre-Bosquet N, Gallouët AS, LeGrand R, Wilson DS, Kontos S, Hubbell JA. Tremain AC, et al. Nat Biomed Eng. 2023 Sep;7(9):1142-1155. doi: 10.1038/s41551-023-01086-2. Epub 2023 Sep 7. Nat Biomed Eng. 2023. PMID: 37679570
Multimodal mucosal and systemic immune characterization of a non-human primate trachoma model highlights the critical role of local immunity during acute phase disease.
Paulet E, Contreras V, Galhaut M, Rosenkrands I, Holland M, Burton M, Dietrich J, Gallouet AS, Bosquet N, Relouzat F, Langlois S, Follmann F, Le Grand R, Labetoulle M, Rousseau A. Paulet E, et al. Among authors: le grand r. PLoS Negl Trop Dis. 2024 Aug 2;18(8):e0012388. doi: 10.1371/journal.pntd.0012388. eCollection 2024 Aug. PLoS Negl Trop Dis. 2024. PMID: 39093884 Free PMC article.
The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection.
Lécuyer D, Nardacci R, Tannous D, Gutierrez-Mateyron E, Deva Nathan A, Subra F, Di Primio C, Quaranta P, Petit V, Richetta C, Mostefa-Kara A, Del Nonno F, Falasca L, Marlin R, Maisonnasse P, Delahousse J, Pascaud J, Deprez E, Naigeon M, Chaput N, Paci A, Saada V, Ghez D, Mariette X, Costa M, Pistello M, Allouch A, Delelis O, Piacentini M, Le Grand R, Perfettini JL. Lécuyer D, et al. Among authors: le grand r. Front Immunol. 2023 Oct 18;14:1270081. doi: 10.3389/fimmu.2023.1270081. eCollection 2023. Front Immunol. 2023. PMID: 37920468 Free PMC article.
Azithromycin disrupts apicoplast biogenesis in replicating and dormant liver stages of the relapsing malaria parasites Plasmodium vivax and Plasmodium cynomolgi.
Amanzougaghene N, Tajeri S, Franetich JF, Ashraf K, Soulard V, Bigeard P, Guindo CO, Bouillier C, Lemaitre J, Relouzat F, Legrand R, Kocken CHM, Zeeman AM, Roobsoong W, Sattabongkot J, Yang Z, Snounou G, Mazier D. Amanzougaghene N, et al. Int J Antimicrob Agents. 2024 May;63(5):107112. doi: 10.1016/j.ijantimicag.2024.107112. Epub 2024 Feb 15. Int J Antimicrob Agents. 2024. PMID: 38367843 Free article.
Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β.
De Groof TWM, Lauwers Y, De Pauw T, Saxena M, Vincke C, Van Craenenbroeck J, Chapon C, Le Grand R, Raes G, Naninck T, Van Ginderachter JA, Devoogdt N. De Groof TWM, et al. Among authors: le grand r. Eur J Nucl Med Mol Imaging. 2024 Dec;52(1):193-207. doi: 10.1007/s00259-024-06896-3. Epub 2024 Sep 2. Eur J Nucl Med Mol Imaging. 2024. PMID: 39218831 Free PMC article.
360 results