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High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma.
Arang N, Lubrano S, Ceribelli M, Rigiracciolo DC, Saddawi-Konefka R, Faraji F, Ramirez SI, Kim D, Tosto FA, Stevenson E, Zhou Y, Wang Z, Bogomolovas J, Molinolo AA, Swaney DL, Krogan NJ, Yang J, Coma S, Pachter JA, Aplin AE, Alessi DR, Thomas CJ, Gutkind JS. Arang N, et al. Among authors: gutkind js. Cell Rep Med. 2023 Nov 21;4(11):101244. doi: 10.1016/j.xcrm.2023.101244. Epub 2023 Oct 18. Cell Rep Med. 2023. PMID: 37858338 Free PMC article.
A Network Landscape of HPVOPC Reveals Methylation Alterations as Significant Drivers of Gene Expression via an Immune-Mediated GPCR Signal.
Qualliotine JR, Nakagawa T, Rosenthal SB, Sadat S, Ballesteros-Merino C, Xu G, Mark A, Nasamran A, Gutkind JS, Fisch KM, Guo T, Fox BA, Khan Z, Molinolo AA, Califano JA. Qualliotine JR, et al. Among authors: gutkind js. Cancers (Basel). 2023 Sep 1;15(17):4379. doi: 10.3390/cancers15174379. Cancers (Basel). 2023. PMID: 37686653 Free PMC article.
A genome-wide CRISPR screen reveals that antagonism of glutamine metabolism sensitizes head and neck squamous cell carcinoma to ferroptotic cell death.
Allevato MM, Trinh S, Koshizuka K, Nachmanson D, Nguyen TC, Yokoyama Y, Wu X, Andres A, Wang Z, Watrous J, Molinolo AA, Mali P, Harismendy O, Jain M, Wild R, Gutkind JS. Allevato MM, et al. Among authors: gutkind js. Cancer Lett. 2024 Aug 28;598:217089. doi: 10.1016/j.canlet.2024.217089. Epub 2024 Jul 2. Cancer Lett. 2024. PMID: 38964731
Mouse Models for Head and Neck Squamous Cell Carcinoma.
Zhou J, Liu C, Amornphimoltham P, Cheong SC, Gutkind JS, Chen Q, Wang Z. Zhou J, et al. Among authors: gutkind js. J Dent Res. 2024 Jun;103(6):585-595. doi: 10.1177/00220345241240997. Epub 2024 May 9. J Dent Res. 2024. PMID: 38722077 Review.
The landscape of cancer-rewired GPCR signaling axes.
Arora C, Matic M, Bisceglia L, Di Chiaro P, De Oliveira Rosa N, Carli F, Clubb L, Nemati Fard LA, Kargas G, Diaferia GR, Vukotic R, Licata L, Wu G, Natoli G, Gutkind JS, Raimondi F. Arora C, et al. Among authors: gutkind js. Cell Genom. 2024 May 8;4(5):100557. doi: 10.1016/j.xgen.2024.100557. Cell Genom. 2024. PMID: 38723607 Free PMC article.
545 results